Merrick Y, Hansen H S
Department of Oncology ONA, Finsen Institute, Copenhagen, Denmark.
Eur J Surg Oncol. 1989 Feb;15(1):49-53.
From 1960 to 1985, 20 patients (12 females and eight males) with thyroid cancer, developed before the age of 20, have been registered and observed at the Radium Center, The Finsen Institute. Papillary adenocarcinoma was diagnosed in 11 cases, and mixed papillary/follicular adenocarcinoma in six cases. Three patients had medullary carcinoma. No patients had previously received cervical irradiation. On admission, lung metastases were evident in two cases. All patients underwent surgical treatment, which in 15 cases consisted of total thyroidectomy, and in nine also lymph node dissection. External irradiation was given to 10 patients, and radioiodine treatment was performed in five patients. Local and/or distant relapse of the thyroid carcinoma occurred in five cases: three were patients with medullary carcinoma, and two had papillary and mixed adenocarcinoma. The three patients with medullary carcinoma died of their disease, but the other two with recurrence recovered after surgery, external irradiation and/or radioiodine treatment. Currently, 16 patients are alive without evidence of disease. The period of follow-up ranged from 2 to 23 years.
1960年至1985年期间，镭中心（芬森研究所）登记并观察了20例20岁之前患甲状腺癌的患者（12名女性和8名男性）。11例诊断为乳头状腺癌，6例为乳头状/滤泡状混合腺癌。3例为髓样癌。所有患者此前均未接受过颈部放疗。入院时，2例有明显的肺转移。所有患者均接受了手术治疗，其中15例行甲状腺全切术，9例还进行了淋巴结清扫。10例患者接受了外照射，5例患者进行了放射性碘治疗。甲状腺癌局部和/或远处复发5例：3例为髓样癌患者，2例为乳头状和混合腺癌患者。3例髓样癌患者死于该病，但另外2例复发患者经手术、外照射和/或放射性碘治疗后康复。目前，16例患者存活，无疾病证据。随访时间为2至23年。
