Ortel B, Sivayathorn A, Hönigsmann H
Department of Dermatology I, University of Vienna, Austria.
Dermatologica. 1989;178(1):39-42. doi: 10.1159/000248385.
A 12-year-old boy developed a phototoxic rash with subsequent progression to Stevens-Johnson syndrome due to prophylactic ingestion of antimalarials (chloroquine and sulfadoxine-pyrimethamine; Fansidar). The patient recovered from his skin symptoms after 4 weeks during which he received systemic corticosteroids and antibiotics. This unusual combination of two different patterns of adverse cutaneous drug reactions was most probably caused by the sulfonamide component of Fansidar.
一名12岁男孩因预防性服用抗疟药（氯喹和磺胺多辛-乙胺嘧啶；Fansidar）出现光毒性皮疹，随后进展为史蒂文斯-约翰逊综合征。患者在接受全身用皮质类固醇和抗生素治疗的4周后皮肤症状痊愈。这种两种不同类型皮肤药物不良反应的不寻常组合很可能是由Fansidar的磺胺类成分引起的。
