仔猪罕见先天性震颤中类猪圆环病毒样病毒 P1 的证据。

Evidence of porcine circovirus-like virus P1 in piglets with an unusual congenital tremor.

机构信息

Jiangsu Academy of Agricultural Sciences Key Laboratory of Animal Diseases, Diagnostics, and Immunology, Institute of Veterinary Medicine, Ministry of Agriculture National Center for Engineering Research of Veterinary Bio-products, Nanjing, China.

出版信息

Transbound Emerg Dis. 2018 Apr;65(2):e501-e504. doi: 10.1111/tbed.12772. Epub 2017 Nov 27.

DOI:10.1111/tbed.12772

PMID:29178610

Abstract

Outbreaks of trembling and shaking were reported among pigs at two pig farms in Jiangsu Province, China. Serum and tissue samples tested positive for porcine circovirus-like virus P1 and negative for classical swine fever virus, porcine circovirus type 2, astrovirus and porcine pestivirus using PCR/RT-PCR and immunohistochemical techniques. High P1 viral genome loads were identified in sera, brain and lymph node tissue samples by qPCR. In addition, one of the most notable pathological changes was dissolution of the nucleus in Purkinje cells. The results of this study provide molecular evidence of an association between congenital tremor in pigs and P1 virus.

摘要

在中国江苏省的两个养猪场，报告了猪群爆发颤抖和抽搐的疫情。采用 PCR/RT-PCR 和免疫组化技术对血清和组织样本进行检测，结果显示猪圆环病毒样病毒 P1 呈阳性，而经典猪瘟病毒、猪圆环病毒 2 型、星状病毒和猪瘟病毒呈阴性。qPCR 检测结果显示，血清、脑组织和淋巴结组织样本中的 P1 病毒基因组载量较高。此外，最显著的病理变化之一是浦肯野细胞的核溶解。本研究结果为先天性震颤与 P1 病毒之间的关联提供了分子证据。