Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences·Key Laboratory of Animal Diseases, Diagnostics, and Immunology, Ministry of Agriculture·Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Nanjing, China.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infections Diseases and Zoonoses, Yangzhou, China.
Transbound Emerg Dis. 2018 Oct;65(5):1133-1136. doi: 10.1111/tbed.12896. Epub 2018 May 14.
Porcine circovirus-like virus P1 is a novel unclassified circovirus that was first detected in China and may be associated with post-weaning multisystemic wasting syndrome (PMWS) and congenital tremor. In this study, we detected P1 infection in pigs in Hebei Province, China, in 2017. One hundred and forty of 500 (28.0%) serum samples from 25 pig farms with different PMWS status in seven cities were P1 positive on PCR. Twelve P1 strains were sequenced, and the complete genomes of 11 P1 strains were 648 nucleotides (nt) in length, whereas that of strain ZJK02 was 647 nt, with a G deletion at position of 183 in its genome. The complete genomic and capsid protein sequences of the 12 P1 strains analysed in this study shared 98.8%-100.0% and 86.5%-100.0% identity, respectively. A phylogenetic analysis based on the complete genomic and capsid sequences of 26 P1 strains showed that the 12 P1 sequences from Hebei Province clustered on two small branches. Further studies of the evolution and pathogenesis of P1 are required.
猪圆环病毒样病毒 P1 是一种新型未分类圆环病毒，最初在中国被发现，可能与断奶后多系统衰弱综合征 (PMWS) 和先天性震颤有关。本研究于 2017 年在中国河北省的猪群中检测到 P1 感染。在七个城市的 25 个具有不同 PMWS 状态的猪场的 500 份血清样本中，有 140 份（28.0%）经 PCR 检测为 P1 阳性。对 12 株 P1 株进行了测序，其中 11 株的完整基因组长 648 个核苷酸 (nt)，而 ZJK02 株的基因组长 647 nt，在其基因组 183 位有一个 G 缺失。本研究分析的 12 株 P1 株的完整基因组和衣壳蛋白序列的同源性分别为 98.8%-100.0%和 86.5%-100.0%。基于 26 株 P1 株的完整基因组和衣壳序列的系统进化分析表明，来自河北省的 12 株 P1 序列聚类在两个小分支上。需要进一步研究 P1 的进化和发病机制。
