Department of Neurology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China.
Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Sci Rep. 2017 Nov 27;7(1):16435. doi: 10.1038/s41598-017-16715-5.
Enlarged perivascular spaces (EPVS) are reported to be associated with impaired cognitive function and sleep disorders. It is of clinical importance to understand the risk factors for EPVS. Hyperuricemia increases the risk of hypertension and endothelial dysfunction, which are well recognized to be associated with EPVS. Therefore, we postulated that serum uric acid (SUA) might be associated with EPVS. A total of 665 lacunar stroke patients were enrolled in this study. The SUA concentrations of patients with severe EPVS were much higher than those of patients with mild EPVS (for basal ganglia: 5.25 ± 1.40 mg/dl vs. 4.75 ± 1.40 mg/dl, p < 0.001; for white matter: 5.31 ± 1.41 mg/dl vs. 4.88 ± 1.37 mg/dl, p = 0.009). The percentage of subjects with severe EPVS tended to be higher in the highest quartile of SUA (chi-square test: P = 0.002 for basal ganglia and 0.006 for white matter). Spearman correlation analysis indicated that the SUA concentrations were positively correlated with the severity of EPVS (rho > 0, p < 0.05). Multivariate logistic regression analysis showed that high normal SUA was independently associated with a higher severity of EPVS. This finding suggests that high SUA levels might be an independent risk factor for EPVS in lacunar stroke patients.
腔隙性脑梗死患者血管周围间隙扩大与认知功能障碍和睡眠障碍有关。了解血管周围间隙扩大的危险因素具有重要的临床意义。高尿酸血症增加了高血压和内皮功能障碍的风险，而高血压和内皮功能障碍与血管周围间隙扩大密切相关。因此，我们推测血清尿酸（SUA）可能与血管周围间隙扩大有关。本研究共纳入 665 例腔隙性脑梗死患者。重度血管周围间隙扩大患者的 SUA 浓度明显高于轻度血管周围间隙扩大患者（基底节：5.25±1.40mg/dl 比 4.75±1.40mg/dl，p<0.001；白质：5.31±1.41mg/dl 比 4.88±1.37mg/dl，p=0.009）。SUA 最高四分位数患者中重度血管周围间隙扩大的比例较高（卡方检验：基底节为 P=0.002，白质为 P=0.006）。Spearman 相关分析表明，SUA 浓度与血管周围间隙扩大的严重程度呈正相关（rho>0，p<0.05）。多变量 logistic 回归分析显示，正常高值的 SUA 与血管周围间隙扩大的严重程度独立相关。这一发现提示，高 SUA 水平可能是腔隙性脑梗死患者血管周围间隙扩大的一个独立危险因素。
