Cheng Kao-Chi, Liao Kuan-Fu, Lin Cheng-Li, Lai Shih-Wei
College of Medicine, China Medical University, Taichung, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Front Psychiatry. 2017 Nov 13;8:235. doi: 10.3389/fpsyt.2017.00235. eCollection 2017.
BACKGROUND/OBJECTIVE: Tuberculosis (TB) and depression were major public health issues worldwide and the mutual causative relationships between them were not exhaustive. This study was performed to explore the association between depression, comorbidities, and the risk of pulmonary TB in Taiwan.
The cohort study used the database of the Taiwan National Health Insurance Program. The depression group included 34,765 subjects aged 20-84 years with newly diagnosed depression from 2000 to 2012, and the non-depression group included 138,187 randomly selected subjects without depression. Both depression and non-depression groups were matched with respect to sex, age, and comorbidities. We explored the incidence of pulmonary TB at the end of 2013 in both the groups and used multivariable Cox proportional hazards regression model to explore the hazard ratio (HR) and 95% confidence interval (CI) for the risk of pulmonary TB associated with depression.
The overall incidence of pulmonary TB was 1.16-fold greater in the depression group than that in the non-depression group (1.52 vs. 1.31 per 1,000 person-years, 95% CI 1.12, 1.21). The multivariable Cox proportional hazards regression analysis revealed that the adjusted HR of pulmonary TB was 1.15 for the depression group (95% CI 1.03, 1.28), compared with the non-depression group.
Depression is associated with 1.15-fold increased hazard of pulmonary TB in Taiwan.
背景/目的：结核病（TB）和抑郁症是全球主要的公共卫生问题，它们之间的相互因果关系尚未完全明确。本研究旨在探讨台湾地区抑郁症、合并症与肺结核风险之间的关联。
队列研究使用了台湾国民健康保险计划的数据库。抑郁症组包括2000年至2012年新诊断为抑郁症的34765名20 - 84岁的受试者，非抑郁症组包括138187名随机选择的无抑郁症受试者。抑郁症组和非抑郁症组在性别、年龄和合并症方面进行了匹配。我们探讨了两组在2013年底肺结核的发病率，并使用多变量Cox比例风险回归模型来探讨与抑郁症相关的肺结核风险的风险比（HR）和95%置信区间（CI）。
抑郁症组肺结核的总体发病率比非抑郁症组高1.16倍（每1000人年1.52例 vs. 1.31例，95% CI 1.12, 1.21）。多变量Cox比例风险回归分析显示，与非抑郁症组相比，抑郁症组肺结核的调整后HR为1.15（95% CI 1.03, 1.28）。
在台湾地区，抑郁症与肺结核风险增加1.15倍相关。
