Rivera-Cruz Cosette M, Shearer Joseph J, Figueiredo Neto Manoel, Figueiredo Marxa L
Department of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
Stem Cells Int. 2017;2017:4015039. doi: 10.1155/2017/4015039. Epub 2017 Oct 17.
Mesenchymal stem cells (MSCs) represent a promising tool for cell therapy, particularly for their antitumor effects. This cell population can be isolated from multiple tissue sources and also display an innate ability to home to areas of inflammation, such as tumors. Upon entry into the tumor microenvironment niche, MSCs promote or inhibit tumor progression by various mechanisms, largely through the release of soluble factors. These factors can be immunomodulatory by activating or inhibiting both the adaptive and innate immune responses. The mechanisms by which MSCs modulate the immune response are not well understood. Because of this, the relationship between MSCs and immune cells within the tumor microenvironment niche continues to be an active area of research in order to help explain the apparent contradictory findings currently available in the literature. The ongoing research aims to enhance the potential of MSCs in future therapeutic applications.
间充质干细胞（MSCs）是细胞治疗的一种有前景的工具，尤其是因其抗肿瘤作用。这种细胞群体可以从多种组织来源中分离出来，并且还表现出归巢至炎症区域（如肿瘤）的先天能力。进入肿瘤微环境生态位后，MSCs通过多种机制促进或抑制肿瘤进展，主要是通过释放可溶性因子。这些因子可通过激活或抑制适应性和先天性免疫反应来调节免疫。MSCs调节免疫反应的机制尚未完全了解。因此，肿瘤微环境生态位内MSCs与免疫细胞之间的关系仍是一个活跃的研究领域，以帮助解释目前文献中明显矛盾的发现。正在进行的研究旨在提高MSCs在未来治疗应用中的潜力。
