College of Science, Nanjing Forestry University , Nanjing 210037, People's Republic of China.
College of Pharmacy, Nanjing University of Chinese Medicine , Nanjing 210023, People's Republic of China.
J Org Chem. 2018 Jan 5;83(1):69-74. doi: 10.1021/acs.joc.7b02076. Epub 2017 Dec 7.
The well-defined heavy rare-earth ytterbium iodide complex 1 (LYbI) has been successfully employed as an efficient catalyst for the hydroboration of a wide range of aldehydes and ketones with pinacolborane (HBpin) at room temperature. The protocol requires low catalyst loadings (0.1-0.5 mol %) and proceeds rapidly (>99% conversion in <10 min). Additionally, catalyst 1 shows a good functional group tolerance even toward the hydroxyl and amino moieties and displays chemoselective hydroboration of aldehydes over ketones under mild conditions.
结构明确的重稀土元素碘化镱配合物 1（LYbI）已成功用作室温下用频哪醇硼烷（HBpin）对各种醛和酮进行硼氢化反应的有效催化剂。该方案需要低催化剂负载量（0.1-0.5 mol%），并且反应迅速（<10 分钟内转化率>99%）。此外，催化剂 1 甚至对羟基和氨基部分具有良好的官能团耐受性，并在温和条件下显示出对醛的选择性硼氢化反应。
