Centre for Human Psychopharmacology, Faculty of Heath, Arts and Design, Swinburne University of Technology, Melbourne, Victoria, Australia.
Centre for Mental Health, Faculty of Heath, Arts and Design, Swinburne University of Technology, Melbourne, Victoria, Australia.
Psychiatry Res Neuroimaging. 2018 Jan 30;271:1-7. doi: 10.1016/j.pscychresns.2017.11.012. Epub 2017 Nov 21.
Auditory processing deficits are frequently identified in autism and schizophrenia, and the two disorders have been shown to share psychosocial difficulties. This study used magnetoencephalography to investigate auditory processing differences for those with a high degree of a non-clinical autistic and schizotypal trait phenotype, Social Disorganisation (SD). Participants were 18 low (9 female) and 19 high (9 female) SD scorers (18-40 years) who completed a three-stimulus auditory oddball paradigm of speech sounds (standard: 100ms 'o', deviant: 150ms 'o', novel: 150ms 'e'). Spatio-temporal cluster analysis revealed increased amplitude for the high SD group in a left (p = 0.006) and a right (p = 0.020) hemisphere cluster in response to the novel non-target. No cluster differences were found in response to the target deviant. These findings suggest that those with a high degree of the SD phenotype recruit more cortical resources when processing unattended, novel speech stimuli, which may lead to psychosocial deficits.
听觉处理缺陷在自闭症和精神分裂症中经常被发现，并且这两种疾病已被证明具有共同的社会心理困难。本研究使用脑磁图来研究具有高度非临床自闭症和精神分裂样特质表型（社会失序）的人的听觉处理差异。参与者包括 18 名低（9 名女性）和 19 名高（9 名女性）SD 评分者（18-40 岁），他们完成了一个三刺激听觉奇偶范式的语音声音（标准：100ms' o '，偏差：150ms' o '，新颖：150ms' e '）。时空聚类分析显示，高 SD 组在左（p = 0.006）和右（p = 0.020）半球簇中对新颖的非目标刺激的振幅增加。在对目标偏差的反应中没有发现聚类差异。这些发现表明，具有高度 SD 表型的人在处理未注意到的新颖语音刺激时会调用更多的皮质资源，这可能导致社会心理缺陷。
