Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Ethnopharmacol. 2018 Mar 1;213:384-394. doi: 10.1016/j.jep.2017.11.028. Epub 2017 Nov 26.
Psydrax subcordata (DC.) Bridson is a tropical medicinal plant used traditionally for the management of epilepsy. However, there is little scientific evidence to support its use.
The current study investigated the anticonvulsant properties of the hydroethanolic leaf extract of Psydrax subcordata (PSE) in animal models.
The anticonvulsant effects were evaluated in mouse models of acute seizures (pentylenetetrazole-, picrotoxin-, 4-aminopyridine-, strychnine- and maximal electroshock-induced seizure tests) and status epilepticus (Lithium/pilocarpine-induced SE). The role of GABAergic mechanisms in the actions of the extract was also examined by pre-treatment of animals with flumazenil in the pentylenetetrazole test.
The extract (30, 100 and 300mg/kg, p.o.) significantly delayed the onset and decreased the duration and frequency of pentylenetetrazole- and picrotoxin-convulsions. PSE also reduced the duration of tonic hind limb extensions in the maximal electroshock-induced seizure test. Furthermore, PSE pre-treatment significantly delayed the onset of seizures and improved survival in the 4-aminopyridine-induced seizure test. In the strychnine-induced seizure test, PSE treatment did not significantly affect the latency to convulsions and time until death when compared to controls. PSE exhibited anticonvulsant effects in the lithium/pilocarpine test by delaying the onset of seizures and status epilepticus as well as reducing the severity of seizures and mortality of mice. Again, the anticonvulsant effect of PSE (100mg/kg, p.o.) was blocked by pre-treatment with flumazenil in the PTZ test.
PSE has anticonvulsant activity in animal models, and this effect may be mediated, at least partly, through GABAergic mechanisms.
Psydrax subcordata（DC.）Bridson 是一种热带药用植物，传统上用于治疗癫痫。然而，目前几乎没有科学证据支持其使用。
本研究旨在研究 Psydrax subcordata（PSE）水醇提叶提取物的抗惊厥特性。
在急性惊厥模型（戊四氮、苦毒蕈碱、4-氨基吡啶、士的宁和最大电休克诱导惊厥试验）和癫痫持续状态（锂/匹罗卡品诱导 SE）中评估了抗惊厥作用。通过在戊四氮试验中用氟马西尼预处理动物，还研究了提取物作用中 GABA 能机制的作用。
该提取物（30、100 和 300mg/kg，po）显著延迟戊四氮和苦毒蕈碱惊厥的发作，并减少其持续时间和频率。PSE 还减少了最大电休克诱导惊厥试验中强直后肢伸展的持续时间。此外，PSE 预处理可显著延迟 4-氨基吡啶诱导惊厥试验中惊厥的发作并提高存活率。在士的宁诱导惊厥试验中，与对照组相比，PSE 治疗并未显著影响惊厥潜伏期和死亡时间。PSE 在锂/匹罗卡品试验中表现出抗惊厥作用，通过延迟发作和癫痫持续状态的发作，以及降低惊厥的严重程度和小鼠的死亡率。同样，PSE（100mg/kg，po）的抗惊厥作用在戊四氮试验中被氟马西尼预处理所阻断。
PSE 在动物模型中具有抗惊厥活性，这种作用至少部分是通过 GABA 能机制介导的。
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