Son Christina H, Fleming Gini F, Moroney John W
Department of Radiation & Cellular Oncology, University of Chicago Medicine.
Section of Hematology/Oncology, Department of Medicine, University of Chicago Medicine.
Cancer Manag Res. 2017 Oct 31;9:553-563. doi: 10.2147/CMAR.S116683. eCollection 2017.
Immune checkpoint inhibitors have become an area of intense interest in oncology and are actively being studied in a variety of cancer types with a wide range of success. In vitro data suggest mechanisms by which radiation can activate the immune system, and ongoing studies are exploring the potential interaction of checkpoint inhibitors with radiotherapy in both preclinical and clinical settings. Gynecologic malignancies are a heterogeneous group of tumors with varying prognoses, intrinsic immunogenicity, and potential for response to immune-based therapies. In this review, we focus on the rationale for immunotherapy and opportunities for augmentation by photon radiotherapy in cancers of the cervix, endometrium, and ovary.
免疫检查点抑制剂已成为肿瘤学领域的一个热门研究方向，并正在多种癌症类型中积极开展研究，且取得了广泛的成功。体外数据表明了辐射激活免疫系统的机制，目前正在进行的研究正在探索检查点抑制剂与放疗在临床前和临床环境中的潜在相互作用。妇科恶性肿瘤是一组异质性肿瘤，具有不同的预后、内在免疫原性以及对基于免疫疗法的反应潜力。在本综述中，我们重点关注免疫疗法的基本原理以及光子放疗增强子宫颈癌、子宫内膜癌和卵巢癌免疫治疗效果的机会。
