以富含ω-3的亚麻籽为基础的饮食，在不同发育时期，对遭受应激的大鼠血压的影响。

The influence of a diet based on flaxseed, an omega-3 source, during different developmental periods, on the blood pressure of rats submitted to stress.

作者信息

Meneses Juliana Azevedo de, Trugilho Liana de Araújo, Lima Samantha de Aguiar, Freitas Amanda Carneiro Ferreira, Melo Henrique Saldanha, Ferreira Maitê Rocha, Velarde Luis Guillermo Coca, Brandão Felipe Zandonadi, Rocha Gabrielle de Souza, Boaventura Gilson Teles

机构信息

a Laboratoy of Experimental Nutrition (LabNE), College of Nutrition, Federal Fluminense University (UFF) , Niterói , Brazil.

b Department of Statistical Analysis , Federal Fluminense University (UFF) , Niterói , Brazil.

出版信息

J Matern Fetal Neonatal Med. 2019 May;32(9):1516-1522. doi: 10.1080/14767058.2017.1407309. Epub 2017 Dec 12.

DOI:10.1080/14767058.2017.1407309

PMID:29187002

Abstract

OBJECTIVE

This study aimed to investigate a flaxseed diet during different developmental periods, and its effect on the blood pressure of rats submitted to stress.

METHODS

Fifty-six male rats (F), born from 14 rats (F), were divided into seven groups (n = 8): flaxseed group (FG); flaxseed group gestation and lactation (FG-GL); flaxseed group weaning (FG-W); flaxseed group weaning and stress (FG-WS); flaxseed group stress (FG-S); flaxseed group gestation lactation and weaning (FG-GLW), and control Group (CG). Stress protocol was undertaken for 1 month. Blood pressure was analysed before and after the stress protocol. The left adrenal glands and serum corticosterone levels were analysed.

RESULTS

Systolic blood pressure before stress was lower in all groups with flaxseed diet compared with the CG (p = .00001). After stress, CG showed higher blood pressure compared with FG, FG-GL, and FG-GLW (p = .004). The levels of corticosterone were lower in the FG between all groups (p < .000001) and the CG showed higher compared with FG-W, FG-WS, FG-GL, and FG-GLW (p < .0001). The adrenal gland did not show differences.

CONCLUSIONS

Results suggest a possible factor from a flaxseed diet against the effects of stress on a blood pressure in all periods of life but especially in the gestation and lactation periods.

摘要

目的

本研究旨在调查不同发育时期的亚麻籽饮食及其对遭受应激的大鼠血压的影响。

方法

56只雄性大鼠（F），由14只大鼠（F）所生，分为7组（n = 8）：亚麻籽组（FG）；亚麻籽组妊娠和哺乳期（FG-GL）；亚麻籽组断奶期（FG-W）；亚麻籽组断奶期和应激期（FG-WS）；亚麻籽组应激期（FG-S）；亚麻籽组妊娠、哺乳期和断奶期（FG-GLW），以及对照组（CG）。应激方案持续1个月。在应激方案前后分析血压。分析左肾上腺和血清皮质酮水平。

结果

与CG相比，所有亚麻籽饮食组在应激前的收缩压均较低（p = .00001）。应激后，与FG、FG-GL和FG-GLW相比，CG的血压更高（p = .004）。FG组的皮质酮水平在所有组中最低（p < .000001），与FG-W、FG-WS、FG-GL和FG-GLW相比，CG的皮质酮水平更高（p < .0001）。肾上腺未显示出差异。