Rades Dirk, Bajrovic Amira, Bartscht Tobias
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Department of Radiation Oncology, University Medical Center Eppendorf, Hamburg, Germany.
Anticancer Res. 2017 Dec;37(12):7011-7015. doi: 10.21873/anticanres.12170.
To our knowledge, this is the first study focusing on metastatic spinal cord compression (MSCC) from carcinoma of the salivary glands.
Nine patients receiving radiation alone were evaluated for improvement of motor deficits, post-radiation gait function and survival.
Of nine characteristics (radiation program, age, sex, additional metastases to bone or to other organs, dynamic of motor deficits, pre-radiation gait function, number of vertebrae affected by MSCC, general condition), strong trends were found for associations between improved motor deficits and their dynamic (p=0.05), post-radiation gait function and pre-treatment ambulatory status (p=0.08) and between survival and additional metastases to other organs (p=0.07), dynamic of motor deficits (p=0.07) and general condition (p=0.07). In addition, a survival score was created. Patients with 2-3 points had a significantly better 6-month survival than those with 0-1 points (100% vs. 0%, p=0.027).
Characteristics predicting outcomes identified in this study and the new survival score can guide physicians when making treatment decisions.
据我们所知，这是第一项聚焦于涎腺癌所致转移性脊髓压迫症（MSCC）的研究。
对9例仅接受放疗的患者的运动功能缺损改善情况、放疗后步态功能及生存率进行评估。
在9项特征（放疗方案、年龄、性别、骨或其他器官的额外转移、运动功能缺损的动态变化、放疗前步态功能、受MSCC影响的椎体数量、一般状况）中，发现运动功能缺损改善与其动态变化之间（p = 0.05）、放疗后步态功能与治疗前步行状态之间（p = 0.08）以及生存率与其他器官的额外转移之间（p = 0.07）、运动功能缺损的动态变化之间（p = 0.07）和一般状况之间（p = 0.07）存在显著的关联趋势。此外，创建了一个生存评分。得2 - 3分的患者6个月生存率显著高于得0 - 1分的患者（100%对0%，p = 0.027）。
本研究中确定的预测结果的特征及新的生存评分可为医生在制定治疗决策时提供指导。
