Fradis M, Podoshin L, Ben-David J, Statter P, Pratt H, Nahir M
Department of Otolaryngology, Haifa Medical Center, Israel.
Laryngoscope. 1989 Mar;99(3):325-9. doi: 10.1288/00005537-198903000-00017.
Central nervous system involvement in systemic lupus erythematosus is frequently occult, may be the presenting sign, and is a bad prognostic indicator. At present, there is no reliable, sensitive laboratory test for the evaluation and diagnosis of subclinical central nervous system involvement of the disease. Brainstem auditory evoked potentials with and without increased stimulus rate have been used to diagnose ischemic lesions in the central nervous system. Brainstem auditory evoked potentials, with and without increased stimulus rate, was used to investigate 15 systemic lupus erythematosus patients, 20 normal participants, and 5 patients receiving corticosteroids for bronchial asthma. A significant statistical difference was found in the net effect of increased stimulus rate in comparisons of the systemic lupus erythematosus patients with the normal group. Brainstem auditory evoked potentials, with increased stimulus rate, demonstrated subclinical involvement of the central nervous system in systemic lupus erythematosus, reinforcing the notion that increased stimulus rate measures are sensitive to ischemic changes, in this case, even in neurologically asymptomatic patients.
系统性红斑狼疮累及中枢神经系统常常隐匿，可能是首发症状，并且是不良预后指标。目前，对于该疾病亚临床中枢神经系统受累的评估和诊断，尚无可靠、灵敏的实验室检查。加与不加加快刺激率的脑干听觉诱发电位已用于诊断中枢神经系统的缺血性病变。采用加与不加加快刺激率的脑干听觉诱发电位对15例系统性红斑狼疮患者、20名正常受试者和5例因支气管哮喘接受皮质类固醇治疗的患者进行研究。系统性红斑狼疮患者与正常组比较，加快刺激率的净效应存在显著统计学差异。加快刺激率的脑干听觉诱发电位显示系统性红斑狼疮存在中枢神经系统亚临床受累，强化了加快刺激率测量对缺血性改变敏感的观点，在这种情况下，即使是神经学无症状的患者也是如此。
