用于测量晶状体渐变折射率轮廓变化的全自动激光射线追踪系统。
Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile.
作者信息
Qiu Chen, Maceo Heilman Bianca, Kaipio Jari, Donaldson Paul, Vaghefi Ehsan
机构信息
Department of Physiology, School of Medical Sciences, University of Auckland, New Zealand.
Faculty of Science, Department of Mathematics, University of Auckland, New Zealand.
出版信息
Biomed Opt Express. 2017 Oct 10;8(11):4947-4964. doi: 10.1364/BOE.8.004947. eCollection 2017 Nov 1.
Measuring the lens gradient refractive index (GRIN) accurately and reliably has proven an extremely challenging technical problem. A fully automated laser ray tracing (LRT) system was built to address this issue. The LRT system captures images of multiple laser projections before and after traversing through an lens. These LRT images, combined with accurate measurements of the lens geometry, are used to calculate the lens GRIN profile. Mathematically, this is an ill-conditioned problem; hence, it is essential to apply biologically relevant constraints to produce a feasible solution. The lens GRIN measurements were compared with previously published data. Our GRIN retrieval algorithm produces fast and accurate measurements of the lens GRIN profile. Experiments to study the optics of physiologically perturbed lenses are the future direction of this research.
准确且可靠地测量晶状体渐变折射率（GRIN）已被证明是一个极具挑战性的技术难题。为此构建了一个全自动激光光线追踪（LRT）系统来解决这一问题。LRT系统在激光束穿过晶状体之前和之后捕获多个激光投影的图像。这些LRT图像，结合对晶状体几何形状的精确测量，用于计算晶状体GRIN分布。从数学角度来看，这是一个病态问题；因此，应用生物学相关约束以产生可行的解决方案至关重要。将晶状体GRIN测量结果与先前发表的数据进行了比较。我们的GRIN检索算法能够快速且准确地测量晶状体GRIN分布。研究生理状态受扰晶状体光学特性的实验是本研究的未来方向。
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