G蛋白偶联受体中水分检测方法

Methodologies for the Examination of Water in GPCRs.

作者信息

Bortolato Andrea, Tehan Benjamin G, Smith Robert T, Mason Jonathan S

机构信息

Heptares Therapeutics Ltd., BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire, AL7 3AX, UK.

出版信息

Methods Mol Biol. 2018;1705:207-232. doi: 10.1007/978-1-4939-7465-8_10.

DOI:10.1007/978-1-4939-7465-8_10

PMID:29188565

Abstract

The following chapter examines some of the current "state-of-the-art" tools for predicting, scoring, and examining explicit water molecules in proteins and protein/ligand complexes, highlighting some of the ways information can be readily examined in a manner that is useful in a drug discovery process.

摘要

以下章节将探讨一些当前用于预测、评分和检测蛋白质及蛋白质/配体复合物中明确水分子的“前沿”工具，重点介绍一些能以对药物发现过程有用的方式轻松检测信息的方法。