Department of Nuclear Medicine, Rambam HealthCare Campus & R. Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Curr Pharm Des. 2018;24(7):806-813. doi: 10.2174/1381612824666171129202647.
Nuclear Medicine (NM) imaging plays a major role in the assessment of infection and inflammation. Tracers, including single photon emitting radionuclides for Single Photon Emission Tomography (SPECT) and agents for positron emission tomography (PET), reflect primarily tissue and cellular function or metabolism. In the specific clinical setting of a patient with suspected infectious or inflammatory process, planar scintigraphy, SPECT or PET procedures are used to support a clinically suspected diagnosis. Integrating metabolic and anatomic information using a single SPECT/CT or PET/CT technique has substantially improved the diagnostic accuracy of these imaging tests and advanced the NM technology to be a significant and important tool in the field of infection and inflammation. Diabetes, one of the most prevalent diseases, has a direct relationship with the development of various infection related condition. Due to alterations in different metabolic pathways, imaging of the diabetic patient may be subject to specific pitfalls and obstacles which should be taken into consideration. This review aimed at describing the impact of diabetes and hyperglycemia on NM imaging, with an emphasis on FDGPET/ CT, in specific infectious conditions related to diabetes.
核医学（NM）成像在感染和炎症的评估中起着重要作用。示踪剂，包括单光子发射放射性核素用于单光子发射断层扫描（SPECT）和正电子发射断层扫描（PET）的示踪剂，主要反映组织和细胞功能或代谢。在疑似感染或炎症过程的患者的特定临床环境中，平面闪烁显像、SPECT 或 PET 程序用于支持临床疑似诊断。使用单个 SPECT/CT 或 PET/CT 技术整合代谢和解剖信息，大大提高了这些成像测试的诊断准确性，并将 NM 技术推进到感染和炎症领域的重要工具。糖尿病是最常见的疾病之一，与各种感染相关疾病的发展直接相关。由于不同代谢途径的改变，糖尿病患者的影像学可能会受到特定的陷阱和障碍的影响，这些都应该考虑在内。本综述旨在描述糖尿病和高血糖对 NM 成像的影响，重点是与糖尿病相关的特定感染情况下的 FDGPET/CT。
