Department of Chemistry, School of advanced sciences, VIT University, Vellore-632014, Tamil Nadu, India.
Mini Rev Med Chem. 2018;18(11):969-975. doi: 10.2174/1389557518666171129214336.
Theranostic agents or theranostic imaging as its name suggests is a combination of two terms-'diagnosis' & 'therapy'. Efforts are being made to combine both the terms into clinical formulations. This theranostic imaging is found to be very much significant to complex diseases like cancer and proliferative tumors especially because accurate photocopy for every tumor can be obtained by genomic and proteomic profiling and using such informations in theranostic agents can be constructed or modeled in such a way that it is specific in its action and selective towards the cancer cells only, without causing any adverse effects on the normal tissue cells. By means of nanoplatforms, we can conveniently deliver cancer cell specific targeting ligand or peptide inside the human body. Primary delivery approach comprises of nanoparticles, liposomes, dendrimers, prodrugs, polymersomes, carbon nanotubes and polymeric micelles. Theranostic agents, i.e., therapeutic and diagnostic agents can be physically bound or else they can be bound with polymers which are exclusively designed and this together forms nanocarriers. Hence, the review highlights the advances of nanotechnology that has given us a platform for cancer detection and treatment.
治疗诊断试剂或治疗诊断成像，顾名思义，是由两个术语“诊断”和“治疗”结合而成。目前正在努力将这两个术语结合到临床配方中。这种治疗诊断成像对于癌症和增殖性肿瘤等复杂疾病非常重要，因为通过基因组和蛋白质组分析可以为每个肿瘤获得准确的副本，并在治疗诊断试剂中使用这些信息，可以构建或模拟成针对特定的癌细胞，而不会对正常组织细胞产生任何不良反应。通过纳米平台，我们可以方便地将癌细胞特异性靶向配体或肽递送到体内。主要的传递方法包括纳米颗粒、脂质体、树枝状大分子、前药、聚合物囊泡、碳纳米管和聚合物胶束。治疗诊断试剂，即治疗和诊断试剂，可以物理结合，也可以与专门设计的聚合物结合，这两者共同形成纳米载体。因此，本文综述了纳米技术的进展，为癌症的检测和治疗提供了一个平台。
