Department of General, Digestive, and Endocrine Surgery, Robert Debré University-Hospital, Reims, France.
University of Champagne-Ardennes, Reims, France.
Ann Surg. 2018 Jun;267(6):e101-e103. doi: 10.1097/SLA.0000000000002601.
: Major hepatectomy (MH) can lead to an increasing portal vein pressure (PVP) and to lesions of the hepatic parenchyma. Several reports have assessed the deleterious effect of a high posthepatectomy PVP on the postoperative course of MH. Thus, several surgical modalities of portal inflow modulation (PIM) have been described. As for pharmacological modalities, experimental studies showed a potential efficiency of Somatostatin to reduce PVP and flow. To our knowledge, no previous clinical reports of PIM using somatostatin are available. Herein, we report the results of PIM using somatostatin in 10 patients who underwent MH with post-hepatectomy PVP > 20 mmHg. Our results suggest Somatostatin could be considered as an efficient reversible PIM when PVP decrease is above 2.5 mmHg.
: 肝切除术（MH）可导致门静脉压力（PVP）升高，并导致肝实质损伤。有几项报告评估了高术后 PVP 对 MH 术后过程的有害影响。因此，已经描述了几种门静脉流入调节（PIM）的手术方式。至于药物方式，实验研究表明生长抑素具有降低 PVP 和流量的潜在功效。据我们所知，目前尚无使用生长抑素进行 PIM 的临床报告。在此，我们报告了 10 例 MH 患者使用生长抑素进行 PIM 的结果，这些患者术后 PVP>20mmHg。我们的结果表明，当 PVP 降低超过 2.5mmHg 时，生长抑素可被视为一种有效的可逆性 PIM。
