口腔鳞状细胞癌中的肿瘤芽生：一项荟萃分析。
Tumour budding in oral squamous cell carcinoma: a meta-analysis.
机构信息
Department of Patholosgy, University of Helsinki, Haartmaninkatu 3, PO Box 21, Helsinki FIN-00014, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki, Haartmaninkatu 8, PO Box 63, Helsinki FI-00014, Finland.
出版信息
Br J Cancer. 2018 Feb 20;118(4):577-586. doi: 10.1038/bjc.2017.425. Epub 2017 Nov 30.
Abstract
BACKGROUND
Tumour budding has been reported as a promising prognostic marker in many cancers. This meta-analysis assessed the prognostic value of tumour budding in oral squamous cell carcinoma (OSCC).
METHODS
We searched OvidMedline, PubMed, Scopus and Web of Science for articles that studied tumour budding in OSCC. We used reporting recommendations for tumour marker (REMARK) criteria to evaluate the quality of studies eligible for meta-analysis.
RESULTS
A total of 16 studies evaluated the prognostic value of tumour budding in OSCC. The meta-analysis showed that tumour budding was significantly associated with lymph node metastasis (odds ratio=7.08, 95% CI=1.75-28.73), disease-free survival (hazard ratio=1.83, 95% CI=1.34-2.50) and overall survival (hazard ratio=1.88, 95% CI=1.25-2.82).
CONCLUSIONS
Tumour budding is a simple and reliable prognostic marker for OSCC. Evaluation of tumour budding could facilitate personalised management of OSCC.
摘要
背景
肿瘤芽殖已被报道为许多癌症中很有前途的预后标志物。本荟萃分析评估了肿瘤芽殖在口腔鳞状细胞癌（OSCC）中的预后价值。
方法
我们在 OvidMedline、PubMed、Scopus 和 Web of Science 中搜索了研究 OSCC 中肿瘤芽殖的文章。我们使用报告肿瘤标志物（REMARK）标准的建议来评估有资格进行荟萃分析的研究的质量。
结果
共有 16 项研究评估了肿瘤芽殖在 OSCC 中的预后价值。荟萃分析表明，肿瘤芽殖与淋巴结转移显著相关（优势比=7.08，95%CI=1.75-28.73）、无病生存率（风险比=1.83，95%CI=1.34-2.50）和总生存率（风险比=1.88，95%CI=1.25-2.82）。
结论
肿瘤芽殖是 OSCC 的一种简单可靠的预后标志物。肿瘤芽殖的评估可以促进 OSCC 的个体化管理。
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本文引用的文献
1
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Virchows Arch. 2018 Feb;472(2):231-236. doi: 10.1007/s00428-017-2212-1. Epub 2017 Aug 2.
2
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Br J Cancer. 2017 Sep 5;117(6):856-866. doi: 10.1038/bjc.2017.244. Epub 2017 Jul 27.
3
Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.
Mod Pathol. 2017 Sep;30(9):1299-1311. doi: 10.1038/modpathol.2017.46. Epub 2017 May 26.
4
Tumor budding as a risk factor for nodal metastasis in pT1 colorectal cancers: a meta-analysis.
Hum Pathol. 2017 Jul;65:62-70. doi: 10.1016/j.humpath.2017.04.013. Epub 2017 Apr 22.
5
Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder.
Oncotarget. 2017 May 30;8(22):36099-36114. doi: 10.18632/oncotarget.16432.
6
Reproducibility, repeatability, and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinoma.
J Oral Pathol Med. 2017 Nov;46(10):949-955. doi: 10.1111/jop.12578. Epub 2017 Apr 28.
7
Predictive Significance of Tumor Depth and Budding for Late Lymph Node Metastases in Patients with Clinical N0 Early Oral Tongue Carcinoma.
Head Neck Pathol. 2017 Dec;11(4):477-486. doi: 10.1007/s12105-017-0814-1. Epub 2017 Apr 3.
8
Development of a New Outcome Prediction Model in Early-stage Squamous Cell Carcinoma of the Oral Cavity Based on Histopathologic Parameters With Multivariate Analysis: The Aditi-Nuzhat Lymph-node Prediction Score (ANLPS) System.
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