Almangush Alhadi, Leivo Ilmo, Siponen Maria, Sundquist Elias, Mroueh Rayan, Mäkitie Antti A, Soini Ylermi, Haglund Caj, Nieminen Pentti, Salo Tuula
Department of Pathology, University of Helsinki, Helsinki, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Virchows Arch. 2018 Feb;472(2):231-236. doi: 10.1007/s00428-017-2212-1. Epub 2017 Aug 2.
It is of great clinical importance to identify simple prognostic markers from preoperative biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth of invasion (D), and the combined scores (i.e., budding and depth of invasion (BD) histopathologic model) in preoperative biopsies and the corresponding postoperative specimens of oral tongue squamous cell carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre- and postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity statistics were used. Our results showed statistically significant (P < 0.001) relationship between pre- and postoperative BD scores. There was an agreement between the pre- and postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI 39.4 to 73.7%) and 96.9% specificity (95% CI 89.3 to 99.6%). Our findings suggest that the BD model, analyzed from representative biopsies, could be used for the treatment planning of OTSCC.
从术前活检中识别出能够指导治疗方案制定的简单预后标志物具有重要的临床意义。在此，我们比较了术前活检组织及相应术后标本中口腔舌鳞状细胞癌（OTSCC）的肿瘤芽生（B）、浸润深度（D）以及综合评分（即芽生和浸润深度（BD）组织病理学模型）。对100例接受OTSCC治疗患者的术前和术后样本进行了肿瘤芽生和浸润深度评估，并采用了敏感性和特异性统计方法。我们的结果显示，术前和术后BD评分之间存在统计学显著相关性（P < 0.001）。术前和术后BD模型评分在83例（83%）病例中具有一致性，敏感性为57.1%（95%可信区间39.4%至73.7%），特异性为96.9%（95%可信区间89.3%至99.6%）。我们的研究结果表明，通过对代表性活检组织进行分析的BD模型可用于OTSCC的治疗方案制定。
