Ma Hai Rong, Pan Ping Lei, Sheng Li Qin, Dai Zhen Yu, Wang Gen Di, Luo Rong, Chen Jia Hui, Xiao Pei Rong, Zhong Jian Guo, Shi Hai Cun
Department of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, PR China.
Department of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Oncotarget. 2017 Oct 4;8(54):93196-93208. doi: 10.18632/oncotarget.21475. eCollection 2017 Nov 3.
Many studies have applied arterial spin labeling (ASL) to characterize cerebral perfusion patterns of Alzheimer's disease (AD). However, findings across studies are not conclusive. A quantitatively voxel-wise meta-analysis to pool the resting-state ASL studies that measure regional cerebral blood flow (rCBF) alterations in AD was conducted to identify the most consistent and replicable perfusion pattern using seed-based d mapping. The meta-analysis, including 17 ASL studies encompassing 327 AD patients and 357 healthy controls, demonstrated that decreased rCBF in AD patients relative to healthy controls were consistently identified in the bilateral posterior cingulate cortices (PCC)/precuneus, bilateral inferior parietal lobules (IPLs), and left dorsolateral prefrontal cortex. The meta-regression analysis showed that more severe cognitive impairment in the AD samples correlated with greater decreases of rCBF in the bilateral PCC and left IPL. This study characterizes an aberrant ASL-rCBF perfusion pattern of AD involving the posterior default mode network and executive network, which are implicated in its pathophysiology and hold promise for developing imaging biomarkers.
许多研究已应用动脉自旋标记（ASL）来表征阿尔茨海默病（AD）的脑灌注模式。然而，各项研究的结果并不确凿。我们进行了一项定量体素级荟萃分析，汇总那些测量AD患者静息态ASL、区域脑血流量（rCBF）变化的研究，以使用基于种子点的d映射来识别最一致且可重复的灌注模式。该荟萃分析纳入了17项ASL研究，涵盖327例AD患者和357例健康对照，结果表明，与健康对照相比，AD患者双侧后扣带回皮质（PCC）/楔前叶、双侧下顶叶小叶（IPL）和左侧背外侧前额叶皮质的rCBF持续降低。荟萃回归分析表明，AD样本中更严重的认知障碍与双侧PCC和左侧IPL中rCBF的更大降低相关。本研究表征了AD异常的ASL-rCBF灌注模式，涉及后默认模式网络和执行网络，这与其病理生理学相关，并有望开发成像生物标志物。
