Bischof Gérard N, Jessen Frank, Fliessbach Klaus, Dronse Julian, Hammes Jochen, Neumaier Bernd, Onur Oezguer, Fink Gereon R, Kukolja Juraj, Drzezga Alexander, van Eimeren Thilo
Multimodal Neuroimaging Group Department of Nuclear Medicine University Hospital Cologne Cologne Germany; Cognitive Neuroscience Institute of Neuroscience and Medicine (INM-3)Research Center Jülich Jülich Germany.
German Center for Neurodegenerative Diseases (DZNE) Bonn Germany; Department of Psychiatry University Hospital Cologne Cologne Germany.
Ann Clin Transl Neurol. 2016 Oct 20;3(12):934-939. doi: 10.1002/acn3.339. eCollection 2016 Dec.
In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [F]AV-1451) and beta-amyloid burden (measured with [C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of A and tau to neurodegeneration in Alzheimer's disease.
在一种多模态PET成像方法中，我们确定了神经纤维缠结（用[F]AV-1451测量）和β-淀粉样蛋白负荷（用[C]PiB测量）对阿尔茨海默病患者神经退行性变程度（即通过[F]FDG-PET测量的葡萄糖代谢）的不同贡献。在整个脑区，我们观察到β-淀粉样蛋白负荷和tau沉积对葡萄糖代谢的交互作用，这在顶叶最为明显。β-淀粉样蛋白负荷升高与tau积累对葡萄糖代谢的更强影响相关。我们的数据首次提供了关于A和tau对阿尔茨海默病神经退行性变的不同贡献的体内见解。
