Department of Molecular Biology, College of Natural Sciences and Human Ecology, Dongeui University, Busan, 614-714, South Korea.
Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, 660-702, South Korea.
Phytother Res. 2018 Mar;32(3):504-513. doi: 10.1002/ptr.5996. Epub 2017 Nov 29.
Decoctions obtained from the dried flowers of Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against inflammatory diseases. Recently, many agents that have used for inflammatory diseases are showing anticancer effects. Here, we have isolated polyphenols extracted from lyophilized Lonicera japonica Thunb (PELJ) and investigated the anticancer effects of PELJ on U937 cells. Here, we demonstrated that PELJ induced apoptosis by upregulation of DR4 and Fas, and further it is augmented by suppression of XIAP. In addition, The PELJ-induced apoptosis is at least in part by blocking PI3K/Akt pathway. These findings suggest that PELJ may provide evidence of anticancer activities on U937 cells. Further study for detailed mechanism and the effects on animal models is warranted to determine whether PELJ provide more conclusive evidence that PELJ which may provide a beneficial effect for treating cancer.
从忍冬科（Indongcho）干燥的金银花（Lonicera japonica Thunb.）花中提取的煎剂，一直被民间用于治疗炎症性疾病。最近，许多用于治疗炎症性疾病的药物也显示出抗癌作用。在这里，我们从冻干的忍冬科（Lonicera japonica Thunb.）中分离出多酚提取物（PELJ），并研究了 PELJ 对 U937 细胞的抗癌作用。在这里，我们证明 PELJ 通过上调 DR4 和 Fas 诱导细胞凋亡，并通过抑制 XIAP 进一步增强。此外，PELJ 诱导的细胞凋亡至少部分是通过阻断 PI3K/Akt 通路。这些发现表明 PELJ 可能为 U937 细胞的抗癌活性提供证据。进一步的研究详细的机制和动物模型的影响是必要的，以确定 PELJ 是否提供了更确凿的证据，即 PELJ 可能对治疗癌症有有益的影响。
