Bulut Ozgul, Ince Zeynep, Uzunhan Ozan, Coban Asuman
Division of Neonatology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Blood Coagul Fibrinolysis. 2018 Mar;29(2):220-222. doi: 10.1097/MBC.0000000000000686.
: Renal vein thrombosis in a neonate is a rare but well recognized condition with low mortality but high morbidity. The cause has not been explained clearly yet but is probably a multifactorial process that includes inherited prothrombotic abnormalities. Antenatal onset of renal vein thrombosis is important due to the increased risk for permanent organ damage. We report a case of prenatal thrombosis of the renal veins and the inferior vena cava in a newborn with double heterozygosity for factor V Leiden and prothrombin gene mutations who had persistently impaired renal function requiring chronic peritoneal dialysis.
新生儿肾静脉血栓形成是一种罕见但已被充分认识的疾病，死亡率低但发病率高。病因尚未完全明确，可能是一个多因素过程，包括遗传性血栓前状态异常。肾静脉血栓形成的产前发病很重要，因为永久性器官损伤的风险增加。我们报告了一例新生儿肾静脉和下腔静脉产前血栓形成的病例，该新生儿为因子V莱顿和凝血酶原基因突变的双重杂合子，肾功能持续受损，需要长期腹膜透析。
