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一名新生儿同时存在因子V Leiden和凝血酶原基因G20210A突变的双重杂合性,产前发生肾静脉和下腔静脉血栓形成:一例报告。

Prenatal thrombosis of renal veins and the inferior vena cava in a newborn with double heterozygosity for the factor V Leiden and prothrombin gene G20210A mutations: a case report.

作者信息

Bulut Ozgul, Ince Zeynep, Uzunhan Ozan, Coban Asuman

机构信息

Division of Neonatology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

出版信息

Blood Coagul Fibrinolysis. 2018 Mar;29(2):220-222. doi: 10.1097/MBC.0000000000000686.

Abstract

: Renal vein thrombosis in a neonate is a rare but well recognized condition with low mortality but high morbidity. The cause has not been explained clearly yet but is probably a multifactorial process that includes inherited prothrombotic abnormalities. Antenatal onset of renal vein thrombosis is important due to the increased risk for permanent organ damage. We report a case of prenatal thrombosis of the renal veins and the inferior vena cava in a newborn with double heterozygosity for factor V Leiden and prothrombin gene mutations who had persistently impaired renal function requiring chronic peritoneal dialysis.

摘要

新生儿肾静脉血栓形成是一种罕见但已被充分认识的疾病,死亡率低但发病率高。病因尚未完全明确,可能是一个多因素过程,包括遗传性血栓前状态异常。肾静脉血栓形成的产前发病很重要,因为永久性器官损伤的风险增加。我们报告了一例新生儿肾静脉和下腔静脉产前血栓形成的病例,该新生儿为因子V莱顿和凝血酶原基因突变的双重杂合子,肾功能持续受损,需要长期腹膜透析。

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