Hoefs J C
Department of Medicine, University of California, Irvine, Orange.
Am J Gastroenterol. 1989 Mar;84(3):296-301.
A new method for measuring the quantity of portal blood bypassing the liver (shunted) has been developed and tested in the dog. Shunts were mimicked by the simultaneous infusion of glycocholic acid into a small peripheral portal venule and a peripheral vein. The total infused amount was kept constant, but the ratio at the two infusion sites varied. Determination of the extraction efficiency of the liver by simultaneously measuring the hepatic vein and arterial blood for systemically infused [14C]glycocholic acid permitted the calculation of shunted blood from information provided by the concentration of glycocholic acid in the hepatic vein, artery, and portal vein blood. This method was tested for various proportion of shunting from none to complete. The total hepatic flow was determined with single injection of indocyanine green and the individual arterial and portal vein flows determined with flowmeters. The input ratios of shunting related quite closely to that calculated from the flowmeters or the hepatic extraction ratio.
一种测量绕过肝脏的门静脉血流量（分流）的新方法已被开发出来，并在狗身上进行了测试。通过将甘氨胆酸同时注入一条小的外周门静脉小分支和一条外周静脉来模拟分流。总注入量保持恒定，但两个注入部位的比例不同。通过同时测量肝静脉和动脉血中全身注入的[14C]甘氨胆酸的肝提取效率，可根据肝静脉、动脉和门静脉血中甘氨胆酸的浓度所提供的信息计算分流血液量。该方法针对从无分流到完全分流的各种分流比例进行了测试。用单次注射吲哚菁绿测定总肝血流量，并用流量计测定个体动脉和门静脉血流量。分流的输入比例与根据流量计或肝提取率计算出的比例非常接近。
