来自同一基因的 lncRNAs 和 circRNAs：RNA 剪接的杰作。

LncRNAs and CircRNAs from the same gene: Masterpieces of RNA splicing.

机构信息

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, PR China.

出版信息

Cancer Lett. 2018 Feb 28;415:49-57. doi: 10.1016/j.canlet.2017.11.034. Epub 2017 Nov 28.

DOI:10.1016/j.canlet.2017.11.034

PMID:29196127

Abstract

Accumulating evidence has shown that lncRNAs and circRNAs are novel regulators of gene expression. The discovery of numerous lncRNAs and circRNAs, and investigation into their structures and functions will contribute to our understanding of the pathogenesis of diseases as well as better prevention, diagnosis, and treatment of diseases. There is a close relationship between circRNAs and lncRNAs regarding their origins and functions. Recent studies have shown that non-coding linear and circular transcripts can be transcribed from the same gene and are potential super-enhancers modulating gene transcription. In this review, we summarize the categories, characteristics, biological functions and databases of both lncRNAs and circRNAs, focusing on their transcriptions derived from the same gene, which might give us a deeper understanding of and enable us to better recognize and distinguish their physiological roles.

摘要

越来越多的证据表明，lncRNAs 和 circRNAs 是基因表达的新型调控因子。大量 lncRNAs 和 circRNAs 的发现及其结构和功能的研究将有助于我们了解疾病的发病机制，并更好地预防、诊断和治疗疾病。circRNAs 和 lncRNAs 在起源和功能上有密切的关系。最近的研究表明，非编码线性和环状转录本可以从同一个基因转录而来，并且是潜在的超级增强子，调节基因转录。在这篇综述中，我们总结了 lncRNAs 和 circRNAs 的类别、特征、生物学功能和数据库，重点介绍了它们来源于同一个基因的转录物，这可能使我们更深入地理解它们，并使我们能够更好地识别和区分它们的生理作用。