子宫内单次低剂量镉暴露会导致大鼠胎儿睾丸间质细胞功能障碍。
In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction.
作者信息
Li Xiaojun, Liu Jianpeng, Wu Siwen, Zheng Wenwen, Li Huitao, Bao Suhao, Chen Yong, Guo Xiaoling, Zhang Lei, Ge Ren-Shan
机构信息
Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.
Center of Scientific Research, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.
出版信息
Chemosphere. 2018 Mar;194:57-66. doi: 10.1016/j.chemosphere.2017.11.159. Epub 2017 Nov 28.
Cadmium chloride (Cd) is a potent endocrine disruptor and may cause the malformation in the male reproductive tract. However, the effects of a single in utero exposure to low doses of Cd on fetal Leydig cell development are still unknown. The objective of this study is to investigate the effects of a single in utero exposure to low doses of Cd on rat fetal Leydig cell development. Adult 64-day-old Sprague-Dawley dams received a single intraperitoneal injection of 0, 0.25, 0.5, and 1.0 mg/kg Cd on gestational day 12. Cd dose-dependently reduced testosterone production of fetal testis, lowered fetal Leydig cell numbers, downregulated protein expression levels of Leydig (LHCGR, SCARB1, STAR, CYP11A1, HSD3B1, and CYP17A1), and Sertoli cells (HSD17B3, DHH, and FSHR). In conclusion, our results demonstrated that a single in utero exposure to low doses of Cd blocked fetal Leydig cell development.
氯化镉（Cd）是一种强效的内分泌干扰物，可能会导致雄性生殖道畸形。然而，子宫内单次低剂量接触Cd对胎儿睾丸间质细胞发育的影响仍不清楚。本研究的目的是探讨子宫内单次低剂量接触Cd对大鼠胎儿睾丸间质细胞发育的影响。64日龄的成年斯普拉格-道利母鼠在妊娠第12天接受单次腹腔注射0、0.25、0.5和1.0 mg/kg的Cd。Cd剂量依赖性地降低了胎儿睾丸的睾酮生成，减少了胎儿睾丸间质细胞数量，下调了睾丸间质细胞（LHCGR、SCARB1、STAR、CYP11A1、HSD3B1和CYP17A1）和支持细胞（HSD17B3、DHH和FSHR）的蛋白表达水平。总之，我们的结果表明，子宫内单次低剂量接触Cd会阻碍胎儿睾丸间质细胞的发育。
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