Bilgic S, Tastemir Korkmaz D, Azirak S, Guvenc A N, Kocaman N, Ozer M K
Bratisl Lek Listy. 2017;118(10):618-625. doi: 10.4149/BLL_2017_119.
The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments.
Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into five groups as: group 1: control; group 2: OLZ; group 3: OLZ+TQ-1; group 4: OLZ+TQ-2; and group 5: OLZ+TQ-3.
The results showed that a 2‑week administration of OLZ (4 mg/kg, once a day for the first week, 8 mg/kg once a day for the second week, p.o.) and treatment with TQ (25, 50, 100 mg/kg, once daily, p.o.) significantly reduced weight gain induced by OLZ. In addition, TQ increased the total antioxidant status (TAS), high-density lipoprotein cholesterol (HDL), insulin levels and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), low density lipoprotein cholesterol (LDL), glucose, triglycerides (TG) and total cholesterol (CH) levels significantly (p < 0.05).
This study revealed that treatment with TQ might protect liver tissue against the side-effects of OLZ. TQ could be an effective course of therapy to enhance therapeutic efficacy (Tab. 4, Fig. 4, Ref. 47).
本研究旨在通过组织学和生化评估，在大鼠肝脏实验模型中探究百里醌（TQ）对奥氮平（OLZ）副作用的潜在保护作用。
对35只雌性Sprague Dawley大鼠进行实验。大鼠被随机分为五组：第1组：对照组；第2组：OLZ组；第3组：OLZ + TQ - 1组；第4组：OLZ + TQ - 2组；第5组：OLZ + TQ - 3组。
结果显示，连续2周给予OLZ（4mg/kg，第1周每天1次，第2周每天8mg/kg，口服）以及用TQ（25、50、100mg/kg，每天1次，口服）治疗，可显著减轻OLZ诱导的体重增加。此外，TQ显著提高了总抗氧化状态（TAS）、高密度脂蛋白胆固醇（HDL）、胰岛素水平，并降低了血清氧化应激指数（OSI）、总氧化剂状态（TOS）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、γ-谷氨酰转肽酶（GGT）、低密度脂蛋白胆固醇（LDL）、葡萄糖、甘油三酯（TG）和总胆固醇（CH）水平（p < 0.05）。
本研究表明，TQ治疗可能保护肝组织免受OLZ的副作用影响。TQ可能是提高治疗效果的有效治疗方法（表4，图4，参考文献47）。
