Department of nephrology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, People's Republic of China.
Department of Emergency, China and Japan Friendship Hospital, Peking Union Medical College, Beijing 10073, People's Republic of China.
Immunol Lett. 2018 Feb;194:1-3. doi: 10.1016/j.imlet.2017.11.014. Epub 2017 Dec 2.
There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of heart allograft rejection. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the regulation of immunity and inflammation. Recent discoveries have illustrated the close link between HMGB1 and heart allograft rejection. In this review, we summarize current knowledge of the function of HMGB1 as a ligand that can evoke inflammatory responses and ultimately cause rejection after heart transplantation.
在过去的 45 年中，心脏移植领域取得了重大进展。尽管适应性免疫在心脏同种异体移植排斥反应中的作用已被广泛研究了数十年，但越来越多的证据表明，固有免疫系统也有助于心脏同种异体移植排斥反应的发展。高迁移率族蛋白（HMGB）蛋白，特别是 HMGB1，是自身来源的固有免疫激活剂，在免疫和炎症调节中具有多种功能。最近的发现说明了 HMGB1 与心脏同种异体移植排斥反应之间的密切联系。在这篇综述中，我们总结了 HMGB1 作为配体的功能的最新知识，这种配体可以引发炎症反应，并最终导致心脏移植后的排斥反应。
