Taiminen Tero
Duodecim. 2017;133(1):52-60.
Ketamine infusions administered intravenously 1 to 3 times per week are the quickest and most effective treatment for depression. Short-course ketamine medication is established treatment both for unipolar depression and depressive episodes of bipolar affective disorder. Ketamine is suitable for initiating the treatment for treatment-resistant depression, alleviation of suicidal tendencies, and treatment of depressive patients suffering from simultaneous pain. The safety of prolonged treatment with ketamine is not known to sufficient degree. However, even long periods (up to 1.5 years) of ketamine treatment have not been associated with adverse effects. It would be appropriate to use short-course ketamine treatment more often than is currently done.
每周静脉注射1至3次氯胺酮是治疗抑郁症最快且最有效的方法。短疗程氯胺酮药物治疗是单相抑郁症和双相情感障碍抑郁发作的既定治疗方法。氯胺酮适用于启动难治性抑郁症的治疗、减轻自杀倾向以及治疗同时患有疼痛的抑郁症患者。目前对氯胺酮长期治疗的安全性了解不足。然而，即使是长达1.5年的氯胺酮治疗也未发现有不良反应。比目前更频繁地使用短疗程氯胺酮治疗是合适的。
