Lackova Eliska, Cunderlik Anton, Ticha Lubica, Gabor Maria
1st Clinic of Gynaecology and Obstetrics, Slovak Medical University and University Hospital Bratislava, Slovakia.
1st Pediatric Department, Children's University Hospital Bratislava, Slovakia.
Neuro Endocrinol Lett. 2017 Nov;38(Suppl1):31-34.
The enlargement of suprarenal gland is related to preterm birth and the birth weight. The ultrasound measurement of fetal adrenal gland volume may identify women at risk for impending preterm birth. The aim of our study was to investigate the newborns in the region of western Slovakia followed up due to suprarenal gland enlargement. To set the ratio of prenatally diagnosed suprarenal gland enlargment, postnatal managment and treatment and interventions. The newborns with congenital adrenal hyperplasia were excluded.
We have analyzed 6 years of medical records of all cases from the western Slovakia region of suprarenal gland enlargement encountered to 1st Pediatric Department, Children's University Hospital Bratislava Republic in the time period of January 2010 to Janurary 2016. The diagnosis of suprarenal gland enlargement was set by ultrasound examination performed on the 4th postnatal day as an overall screening test. Newborns with positive laboratory screening on congenital adrenal hyperplasia (CAH) were excluded from our study. We analyzed the origin of surarenal gland enlargement, gestation week on the due date, the birth weight and other comorbidities and genetic pathologies in newborns with the enlarged suprarenal glands.
There were 6 newborns followed up due to suprarenal gland enlargement. All of the patients had diagnosed the adrenal haemorrhage. Adrenal lesions like adrenal cysts or neuroblastomas were not confirmed. All of the adrenal enlargements were benign with no need of other medical or surgical intervention. None of the newborn patients had other genetic abnormalities, mineral or hormonal imbalances, problems with arterial pressure or haemodynamic instability. All of the patients underwent at least 5 prenatal ultrasound tests and at least 2 postnatal ultrasound measurements. The avarage birth weight was 3030 grams (2700 grams - to 3750 grams). The avarage birth lenght was 50 cm (47 centimeter to 53 cm).The average gestation week (gw) on due date was 39 gw. 85% from the patients were born on 40 gw, 15% on 39 gw.
We didn't confirm the relation between the suprarenal gland enlargement and the preterm birth (≤ 34 weeks' gestation). In the period of 6 years we didn't find a newborn patient with the prenatal diagnosis of suprarenal gland enlargement. The adrenal gland enlargement didn't have a relation with the low gestation birth, weight, length or the preterm birth.
肾上腺增大与早产及出生体重有关。超声测量胎儿肾上腺体积可识别有早产风险的女性。我们研究的目的是调查斯洛伐克西部地区因肾上腺增大而接受随访的新生儿。确定产前诊断的肾上腺增大的比例、产后管理及治疗和干预措施。排除患有先天性肾上腺增生的新生儿。
我们分析了2010年1月至2016年1月期间斯洛伐克西部地区所有肾上腺增大病例的6年医疗记录，这些病例均转诊至布拉迪斯拉发共和国儿童医院第一儿科。肾上腺增大的诊断通过出生后第4天进行的超声检查作为全面筛查试验来确定。先天性肾上腺增生（CAH）实验室筛查呈阳性的新生儿被排除在我们的研究之外。我们分析了肾上腺增大新生儿肾上腺增大的原因、预产期的孕周、出生体重以及其他合并症和遗传病理情况。
有6例新生儿因肾上腺增大接受随访。所有患者均被诊断为肾上腺出血。未证实存在肾上腺囊肿或神经母细胞瘤等肾上腺病变。所有肾上腺增大均为良性，无需其他药物或手术干预。所有新生儿患者均无其他遗传异常、矿物质或激素失衡、动脉压问题或血流动力学不稳定情况。所有患者均接受了至少5次产前超声检查和至少2次产后超声测量。平均出生体重为3030克（2700克至3750克）。平均出生身长为50厘米（47厘米至53厘米）。预产期的平均孕周（gw）为39周。85%的患者在40周出生，15%在39周出生。
我们未证实肾上腺增大与早产（孕周≤34周）之间的关系。在6年期间，我们未发现产前诊断为肾上腺增大的新生儿患者。肾上腺增大与低孕周出生、体重、身长或早产无关。
