以谵妄为表现的阿片类药物戒断及丁丙诺啡的作用：病例系列
Opioid Withdrawal Presenting as Delirium and Role of Buprenorphine: A Case Series.
作者信息
Das Sourav, Sah Divyashree, Nandi Shiladitya, Das Payel
机构信息
Antara Psychiatric Centre, Sri Aurobindo Seva Kendra, Kolkata, West Bengal, India.
Department of Psychology, Kumaun University, Nainital, Uttarakhand, India.
出版信息
Indian J Psychol Med. 2017 Sep-Oct;39(5):665-667. doi: 10.4103/0253-7176.217027.
Opioid withdrawal is very rarely characterized by delirium unlike alcohol or benzodiazepine withdrawal. PubMed search through October 2016 reveals only two case series on delirium as feature of withdrawal in opioid dependence syndrome. We report two cases of opioid withdrawal (heroin) presenting with delirium when low-dose buprenorphine (2 mg/day) was added. Both the cases had no other substance abuse history and nil contributory past and family history. Both of them were improved after increasing the buprenorphine dosage to 6-8 mg/day. The possibility of delirium as a part of withdrawal symptom or as a phenomenon induced by buprenorphine or due to impurities in the heroin used is discussed.
与酒精或苯二氮䓬类药物戒断不同，阿片类药物戒断很少以谵妄为特征。截至2016年10月的PubMed搜索显示，仅有两个关于谵妄作为阿片类药物依赖综合征戒断特征的病例系列。我们报告了两例阿片类药物（海洛因）戒断病例，在加用低剂量丁丙诺啡（2毫克/天）时出现谵妄。这两个病例均无其他药物滥用史，既往史和家族史也无相关因素。将丁丙诺啡剂量增加至6 - 8毫克/天后，两人均有所好转。文中讨论了谵妄作为戒断症状的一部分、由丁丙诺啡诱发的现象或因所使用海洛因中的杂质导致的可能性。
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