Huang Xin, Li Dan, Li Hai-Jun, Zhong Yu-Lin, Freeberg Shelby, Bao Jing, Zeng Xian-Jun, Shao Yi
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi, People's Republic of China.
Department of Ophthalmology, Eye Center, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, People's Republic of China.
Neuropsychiatr Dis Treat. 2017 Nov 22;13:2849-2854. doi: 10.2147/NDT.S147645. eCollection 2017.
The aim of the study was to investigate changes of brain neural homogeneity in retinal detachment (RD) patients using the regional homogeneity (ReHo) method to understand their relationships with clinical features.
A total of 30 patients with RD (16 men and 14 women), and 30 healthy controls (HCs) (16 men and 14 women) closely matched in age and sex were recruited. Resting-state functional magnetic resonance imaging scans were performed for all subjects. The ReHo method was used to investigate the brain regional neural homogeneity. Patients with RD were distinguished from HCs by receiver operating characteristic curve. The relationships between the mean ReHo signal values in many brain regions and clinical features in RD patients were calculated by Pearson correlation analysis.
Compared with HCs, RD patients had significantly decreased ReHo values in the right occipital lobe, right superior temporal gyrus, bilateral cuneus and left middle frontal gyrus. Moreover, we found that the mean ReHo signal of the bilateral cuneus showed positive relationships with the duration of the RD (=0.392, =0.032).
The RD patients showed brain neural homogeneity dysfunction in the visual pathway, which may underline the pathological mechanism of RD patients with acute vision loss. Besides, the ReHo values can reflect the progress of the RD disease.
本研究旨在采用局部一致性（ReHo）方法研究视网膜脱离（RD）患者脑神经网络同质性的变化，以了解其与临床特征的关系。
招募30例RD患者（男16例，女14例）和30例健康对照者（HCs）（男16例，女14例），年龄和性别相匹配。对所有受试者进行静息态功能磁共振成像扫描。采用ReHo方法研究脑区神经同质性。通过受试者工作特征曲线将RD患者与HCs区分开来。采用Pearson相关分析计算RD患者多个脑区平均ReHo信号值与临床特征之间的关系。
与HCs相比，RD患者右侧枕叶、右侧颞上回、双侧楔叶和左侧额中回的ReHo值显著降低。此外，我们发现双侧楔叶的平均ReHo信号与RD持续时间呈正相关（r = 0.392，P = 0.032）。
RD患者在视觉通路中存在脑神经网络同质性功能障碍，这可能是RD患者急性视力丧失的病理机制。此外，ReHo值可以反映RD疾病的进展。
