• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Esters of Quinoxaline 1`4-Di--oxide with Cytotoxic Activity on Tumor Cell Lines Based on NCI-60 Panel.基于NCI-60细胞株面板的对肿瘤细胞系具有细胞毒性活性的喹喔啉1,4-二氧化物酯类
Iran J Pharm Res. 2017 Summer;16(3):953-965.
2
Synthesis of quinoxaline 1,4-di-N-oxide analogues and crystal structure of 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide.合成喹喔啉 1,4-二-N-氧化物类似物及 2-甲氧基-3-羟基喹喔啉二-N-氧化物的晶体结构。
Molecules. 2011 Aug 12;16(8):6894-901. doi: 10.3390/molecules16086894.
3
Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives.新型2-烷基羰基和2-苯甲酰基-3-三氟甲基喹喔啉1,4-二氧化物衍生物的合成与抗癌活性评估
Bioorg Med Chem. 2004 Jul 1;12(13):3711-21. doi: 10.1016/j.bmc.2004.04.013.
4
New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides.新型喹喔啉 1,4 - 二氧化物。第1部分：源自喹喔啉 1,4 - 二氧化物的低氧选择性细胞毒素和抗癌剂。
Bioorg Med Chem. 2006 Oct 15;14(20):6917-23. doi: 10.1016/j.bmc.2006.06.038. Epub 2006 Jul 14.
5
Anti- Activity of Esters of Quinoxaline 1,4-Di--Oxide.[喹喔啉 1,4-二--氧化物的酯的抗活性]。
Molecules. 2018 Jun 15;23(6):1453. doi: 10.3390/molecules23061453.
6
Biological activity of esters of quinoxaline-7-carboxylate 1,4-di-N-oxide against E. histolytica and their analysis as potential thioredoxin reductase inhibitors.醌嗪-7-羧酸 1,4-二-N-氧化物酯对溶组织内阿米巴的生物活性及其作为潜在的硫氧还蛋白还原酶抑制剂的分析。
Parasitol Res. 2020 Feb;119(2):695-711. doi: 10.1007/s00436-019-06580-8. Epub 2020 Jan 6.
7
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?喹喔啉 1,4-二-N-氧化物衍生物：它们是非选择性还是选择性抑制剂？
Mini Rev Med Chem. 2022;22(1):15-25. doi: 10.2174/1389557521666210126142541.
8
Ester of Quinoxaline-7-carboxylate 1,4-di-N-oxide as Apoptosis Inductors in K-562 Cell Line: An in vitro, QSAR and DFT Study.喹喔啉-7-羧酸1,4-二氮氧化物酯作为K-562细胞系中的凋亡诱导剂：一项体外、定量构效关系和密度泛函理论研究
Anticancer Agents Med Chem. 2017;17(5):682-691. doi: 10.2174/1871520616666160630175927.
9
Quinoxaline 1,4-di--oxide Derivatives as New Antinocardial Agents.喹喔啉 1,4-二氧化物衍生物作为新型抗心肌药物。
Molecules. 2024 Sep 30;29(19):4652. doi: 10.3390/molecules29194652.
10
Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.新型2-芳基羰基-3-三氟甲基喹喔啉1,4-二氧化物衍生物及其还原类似物的合成与生物学评价
J Med Chem. 2007 Nov 1;50(22):5485-92. doi: 10.1021/jm0703993. Epub 2007 Oct 2.

引用本文的文献

1
Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di--oxide derivatives against , , and An and approach.拓展喹喔啉-1,4-二--氧化物衍生物的正丁基和异丁基酯的抗原生动物活性和作用机制，以对抗 、 和 。一种 和 方法。
J Enzyme Inhib Med Chem. 2024 Dec;39(1):2413018. doi: 10.1080/14756366.2024.2413018. Epub 2024 Oct 29.
2
In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di--oxide Derivatives against as Trypanothione Reductase Inhibitors.新型 n-丁基和异丁基喹喔啉-7-羧酸 1,4-二--氧化物衍生物抗 作为 硫醇还原酶抑制剂的体外和计算分析。
Int J Mol Sci. 2022 Nov 1;23(21):13315. doi: 10.3390/ijms232113315.

本文引用的文献

1
Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica.合成及新的乙基和甲基喹喔啉-7-羧酸 1,4-二-N-氧化物对溶组织内阿米巴的体外评价。
Bioorg Med Chem. 2013 Aug 1;21(15):4550-8. doi: 10.1016/j.bmc.2013.05.036. Epub 2013 Jun 1.
2
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities.具有抗利什曼原虫和抗疟活性的喹喔啉 1,4-二 N-氧化物的新水杨酰胺和磺胺衍生物。
Bioorg Med Chem Lett. 2011 Aug 1;21(15):4498-502. doi: 10.1016/j.bmcl.2011.05.125. Epub 2011 Jun 12.
3
Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent.取代喹唑啉和喹喔啉衍生物的合成及体外抗肿瘤活性研究：寻找抗癌剂。
Eur J Med Chem. 2011 Jun;46(6):2327-46. doi: 10.1016/j.ejmech.2011.03.015. Epub 2011 Mar 15.
4
Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives.7H-苯并[4,5]吲哚并[2,3-b]喹喔啉衍生物的合成及生物活性。
Eur J Med Chem. 2011 Feb;46(2):794-8. doi: 10.1016/j.ejmech.2010.11.040. Epub 2010 Dec 1.
5
New quinoxaline 1, 4-di-N-oxides: anticancer and hypoxia-selective therapeutic agents.新型喹喔啉 1,4-二 N-氧化物：抗癌和缺氧选择性治疗剂。
Eur J Med Chem. 2010 Jul;45(7):2733-8. doi: 10.1016/j.ejmech.2010.02.052. Epub 2010 Mar 1.
6
Tirapazamine: a novel agent targeting hypoxic tumor cells.替拉扎明：一种靶向缺氧肿瘤细胞的新型药物。
Expert Opin Investig Drugs. 2009 Jan;18(1):77-87. doi: 10.1517/13543780802567250.
7
Synthesis and in vitro antitumor activity of new quinoxaline derivatives.新型喹喔啉衍生物的合成及其体外抗肿瘤活性
Eur J Med Chem. 2009 Apr;44(4):1579-91. doi: 10.1016/j.ejmech.2008.07.025. Epub 2008 Jul 26.
8
Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.一些新型环取代的3-苯基-1-(1,4-二氮氧化物喹喔啉-2-基)-2-丙烯-1-酮衍生物及其4,5-二氢-(1H)-吡唑类似物的合成与抗炎/抗氧化活性
Bioorg Med Chem Lett. 2007 Dec 1;17(23):6439-43. doi: 10.1016/j.bmcl.2007.10.002. Epub 2007 Oct 5.
9
Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.新型2-芳基羰基-3-三氟甲基喹喔啉1,4-二氧化物衍生物及其还原类似物的合成与生物学评价
J Med Chem. 2007 Nov 1;50(22):5485-92. doi: 10.1021/jm0703993. Epub 2007 Oct 2.
10
The NCI60 human tumour cell line anticancer drug screen.美国国立癌症研究所60种人类肿瘤细胞系抗癌药物筛选
Nat Rev Cancer. 2006 Oct;6(10):813-23. doi: 10.1038/nrc1951.

基于NCI-60细胞株面板的对肿瘤细胞系具有细胞毒性活性的喹喔啉1,4-二氧化物酯类

Esters of Quinoxaline 1`4-Di--oxide with Cytotoxic Activity on Tumor Cell Lines Based on NCI-60 Panel.

作者信息

Rivera Gildardo, Ahmad Shah Syed Shoaib, Arrieta-Baez Daniel, Palos Isidro, Mongue Antonio, Sánchez-Torres Luvia Enid

机构信息

Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa, México.

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.

出版信息

Iran J Pharm Res. 2017 Summer;16(3):953-965.

PMID:29201086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5610751/
Abstract

Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 14-di--oxide derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 14-di--oxide substitutes at 7-position with esters group were synthetized and characterized by infrared (IR), proton nuclear magnetic resonance (H-NMR), spectroscopy, and elemental analysis. Seventeen derivatives (M1-M3, E1-E8, P1-P3 and DR1-DR3) were selected and evaluated for antitumor activities using the NCI-60 human tumor cell lines screen. Results showed that E7, P3 and E6 were the most active compounds against the cell lines tested. Substitutions at 7-position with esters group not necessarily affect the biological activity, but the nature of the esters group could exert an influence on the selectivity. Additionally, substitutions at 2-position influenced the cytotoxic activity of the compounds.

摘要

喹喔啉作为抗菌、抗病毒、抗寄生虫和抗癌药物具有多样且有趣的药理活性。特别是，它们的1,4 - 二氧化物衍生物已被证明是细胞毒性药物，在实体瘤的缺氧条件下具有活性。合成了一系列新的在7位带有酯基取代的喹喔啉1,4 - 二氧化物，并通过红外（IR）、质子核磁共振（H - NMR）光谱和元素分析进行了表征。选择了17种衍生物（M1 - M3、E1 - E8、P1 - P3和DR1 - DR3），并使用NCI - 60人肿瘤细胞系筛选评估其抗肿瘤活性。结果表明，E7、P3和E6是针对所测试细胞系最具活性的化合物。7位带有酯基的取代不一定会影响生物活性，但酯基的性质可能会对选择性产生影响。此外，2位的取代会影响化合物的细胞毒性活性。