Liu Huiqin, Mei Wenli, Huang Yue, Li Yongli, Chen Zuzhi, Li Dongdong, Ye Hong, Zhang Jiewen
Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
Department of Radiology, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
Exp Ther Med. 2017 Nov;14(5):5207-5213. doi: 10.3892/etm.2017.5195. Epub 2017 Sep 22.
The location and length of the susceptibility vessel sign (SVS) predicts poor outcome for patients having received reperfusion therapy. The aim of the present study was to assess the predictive value of SVS regarding the clinical outcome for patients untreated with thrombolysis. A retrospective study on acute stroke patients who underwent multimodal magnetic resonance imaging within 3 days from the onset of symptoms was performed. None of the patients had received thrombolysis therapy. The presence, location and length of the SVS were assessed. Uni- and multivariate analyses were used to examine the association between SVS and clinical outcome. A total of 43 SVS+ and 73 SVS- patients were included in the study. A modified Rankin Scale (mRS) of ≤2 at 3 months was determined in 41.9% of patients in the SVS+ group and 79.4% in the SVS- group (P<0.001). Multivariate analysis revealed that the presence of SVS was an independent parameter to predict mRS >2 at 3 months (odds ratio, 3.390; 95% confidence interval, 1.122-10.240; P=0.030). For patients with SVS+ status, the location and length of the SVS were not independent predictors of the clinical outcome. In conclusion, the presence of SVS may predict poor clinical outcome for acute stroke patients untreated with thrombolysis.
易损血管征（SVS）的位置和长度可预测接受再灌注治疗患者的不良预后。本研究的目的是评估SVS对未接受溶栓治疗患者临床结局的预测价值。对症状发作3天内接受多模态磁共振成像的急性卒中患者进行了一项回顾性研究。所有患者均未接受溶栓治疗。评估了SVS的存在、位置和长度。采用单因素和多因素分析来检验SVS与临床结局之间的关联。共有43例SVS阳性和73例SVS阴性患者纳入研究。SVS阳性组41.9%的患者在3个月时改良Rankin量表（mRS）≤2，SVS阴性组为79.4%（P<0.001）。多因素分析显示，SVS的存在是预测3个月时mRS>2的独立参数（比值比，3.390；95%置信区间，1.122 - 10.240；P = 0.030）。对于SVS阳性的患者，SVS的位置和长度不是临床结局的独立预测因素。总之，SVS的存在可能预测未接受溶栓治疗的急性卒中患者的不良临床结局。
