Bartz Deborah, Maurer Rie, Kremen Jessica, Fortin Jennifer M, Janiak Elizabeth, Goldberg Alisa B
The Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 USA.
Planned Parenthood League of Massachusetts, 1055 Commonwealth Ave, Boston, MA 02115 USA.
Contracept Reprod Med. 2017 Jan 7;2:8. doi: 10.1186/s40834-016-0035-0. eCollection 2017.
Depot medroxyprogesterone acetate (DMPA) contraceptive use is associated with an increased risk for infection. However, prior studies inadequately account for potential differences in sexual behavior between users of DMPA and users of other contraceptive methods. In this study we compare sexual risk-taking behavior in women using DMPA to women using oral contraceptive pills (OCP) to assess risk of infection.
In this cross-sectional study of 630 reproductive-aged women seeking routine gynecologic care (449 OCP and 181 DMPA users) sexual risk-taking was evaluated by use of the Safe Sex Behavior Questionnaire, a validated measure of sexual behaviors and attitudes. All women were screened for . Logistic regression estimated the association of contraceptive choice, sexual behaviors, and infection.
Oral contraceptive pill users differed from DMPA users in age, race, marital status, education level, and pregnancy history (-values all <0.05). Oral contraceptive pill users had used their method of contraception for longer average duration ( < 0.01) and reported greater frequency of condom use ( < 0.01). Eleven (2.5%) OCP and 2 (1.1%) DMPA users had ( = NS).
Oral contraceptive pill and DMPA users differed with respect to both demographic factors and frequency of condom use. Odds of current infection did not differ between OCP and DMPA users when controlling for sexual risk-taking or demographic factors, though due to low rates in our population, this study was underpowered to detect this difference.
使用醋酸甲羟孕酮长效避孕针（DMPA）与感染风险增加有关。然而，先前的研究没有充分考虑使用DMPA的人群与使用其他避孕方法的人群在性行为方面的潜在差异。在本研究中，我们比较了使用DMPA的女性与使用口服避孕药（OCP）的女性的性冒险行为，以评估感染风险。
在这项对630名寻求常规妇科护理的育龄妇女进行的横断面研究中（449名OCP使用者和181名DMPA使用者），通过使用《安全性行为问卷》对性冒险行为进行评估，该问卷是一种经过验证的性行为和态度测量工具。所有女性均接受了……筛查。逻辑回归分析估计了避孕选择、性行为与……感染之间的关联。
口服避孕药使用者与DMPA使用者在年龄、种族、婚姻状况、教育水平和妊娠史方面存在差异（所有P值均<0.05）。口服避孕药使用者使用其避孕方法的平均时间更长（P<0.01），并且报告使用避孕套的频率更高（P<0.01）。11名（2.5%）OCP使用者和2名（1.1%）DMPA使用者患有……（P=无显著性差异）。
口服避孕药使用者和DMPA使用者在人口统计学因素和使用避孕套的频率方面均存在差异。在控制了性冒险行为或人口统计学因素后，OCP使用者和DMPA使用者当前感染……的几率没有差异，不过由于我们研究人群中的……感染率较低，本研究检测这种差异的能力不足。
