糖尿病患者的药物性肝病
Drug-induced Liver Disease in Patients with Diabetes Mellitus.
作者信息
Iryna Klyarytskaya, Helen Maksymova, Elena Stilidi
机构信息
Department of Therapy and Family Medicine, Faculty of Postgraduate Education, Medical Academy, SI Georgievsky, Simferopol Crimea, Russian Federation.
出版信息
Euroasian J Hepatogastroenterol. 2015 Jul-Dec;5(2):83-86. doi: 10.5005/jp-journals-10018-1140. Epub 2016 Jul 9.
UNLABELLED
The study presented here was accomplished to assess the course of drug-induced liver diseases in patient's rheumatoid arthritis receiving long-term methotrexate therapy. Diabetes mellitus was revealed as the most significant risk factor. The combination of diabetes mellitus with other risk factors (female sex) resulted in increased hepatic fibrosis, degree of hepatic encephalopathy and reduction of hepatic functions. The effectiveness and safety of ursodeoxycholic acid and cytolytic type-with S-Adenosyl methionine was also evaluated.
ABBREVIATIONS
13C-MBT: 13C-methacetin breath test; ALT: alanine aminotransferase; AP: alkaline phosphatase; AST: aspartic transaminase; DILD: drug-induced liver disease; DM: diabetes mellitus; HE: hepatic encephalopathy; HFM: hepatic functional mass; SAMe: S-Adenosyl methionine; UDCA: ursodeoxycholic acid.
HOW TO CITE THIS ARTICLE
Iryna K, Helen M, Elena S. Drug-induced Liver Disease in Patients with Diabetes Mellitus. Euroasian J Hepato-Gastroenterol 2015;5(2):83-86.
未标注
此处呈现的研究旨在评估接受长期甲氨蝶呤治疗的类风湿关节炎患者药物性肝病的病程。糖尿病被发现是最显著的风险因素。糖尿病与其他风险因素（女性）的组合导致肝纤维化增加、肝性脑病程度加重以及肝功能下降。还评估了熊去氧胆酸和溶细胞型药物与S-腺苷甲硫氨酸的有效性和安全性。
缩写
13C-MBT：13C-美沙西汀呼气试验；ALT：丙氨酸氨基转移酶；AP：碱性磷酸酶；AST：天冬氨酸氨基转移酶；DILD：药物性肝病；DM：糖尿病；HE：肝性脑病；HFM：肝功能性质量；SAMe：S-腺苷甲硫氨酸；UDCA：熊去氧胆酸。
如何引用本文
Iryna K, Helen M, Elena S. 糖尿病患者的药物性肝病。《欧亚肝脏胃肠病学杂志》2015年；5(2):83 - 86。
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