Vrtunski P B, Simpson D M, Meltzer H Y
Cleveland VA Medical Center, Ohio.
Biol Psychiatry. 1989 Mar 1;25(5):529-39. doi: 10.1016/0006-3223(89)90213-8.
Several aspects of fine motor control were compared in schizophrenics and two control populations. The motor behavior analyzed was a button-press response in a forced choice paradigm. Three areas of abnormality were seen in schizophrenics: first, the interval preceding the motor response was characterized by reduced motor steadiness prior to the button-press response; second, the motor response was made with excessive force (hyperdynamia); and third, the agonist-antagonist synchrony (motor reversal) was impaired. Schizophrenics on and off neuroleptics did not differ on any measure of motor control, but schizophrenics with clinically observed tardive dyskinesia were found to have significantly less steadiness prior to the motor response than other schizophrenics.
对精神分裂症患者和两个对照人群的精细运动控制的几个方面进行了比较。所分析的运动行为是强迫选择范式中的按键反应。在精神分裂症患者中发现了三个异常区域：第一，运动反应之前的间隔期，其特征是在按键反应之前运动稳定性降低；第二，运动反应用力过度（运动机能亢进）；第三，主动肌-拮抗肌同步性（运动反转）受损。服用和未服用抗精神病药物的精神分裂症患者在任何运动控制指标上均无差异，但临床观察到有迟发性运动障碍的精神分裂症患者在运动反应前的稳定性明显低于其他精神分裂症患者。
