Koukkou M
Schweiz Arch Neurol Psychiatr (1985). 1985;136(1):37-43.
Studies of the EEG correlates of information processing in normals indicate that different cognitive processing of information is correlated with different functional brain states. Studies in experimental psychology have demonstrated a communication and performance deficit in schizophrenics which indicates a deviation in one or more stages of information processing. Accordingly it can be hypothesized that the functional brain states as manifested in the EEG during information processing in schizophrenics are different from these states in normals or former schizophrenics. The paper tested this hypothesis in drug-free acute and former schizophrenics, neurotics and normals. The results indicate 1) that acute schizophrenics show a deviant electrical brain state during information processing; 2) former schizophrenics in a good clinical remission have electrical brain states during information processing which in some aspects are normalised, and in other aspects still differ from these states in normals and neurotics. The importance of these physiological findings for the assessment of the efficacy of the biological and psychological treatments in schizophrenia is discussed.
对正常人信息处理的脑电图相关性研究表明，不同的信息认知处理与不同的大脑功能状态相关。实验心理学研究已证明精神分裂症患者存在沟通和行为缺陷，这表明在信息处理的一个或多个阶段出现了偏差。因此，可以假设，精神分裂症患者在信息处理过程中脑电图所显示的大脑功能状态与正常人或既往精神分裂症患者的这些状态不同。本文在未用药的急性和既往精神分裂症患者、神经症患者及正常人中对这一假设进行了检验。结果表明：1）急性精神分裂症患者在信息处理过程中表现出异常的脑电状态；2）处于良好临床缓解期的既往精神分裂症患者在信息处理过程中的脑电状态在某些方面已恢复正常，但在其他方面仍与正常人和神经症患者的状态有所不同。本文还讨论了这些生理学发现对评估精神分裂症生物治疗和心理治疗疗效的重要性。
