血浆鞘脂葡萄糖神经酰胺水平较低与血栓性疾病有关。
Low level of the plasma sphingolipid, glucosylceramide, is associated with thrombotic diseases.
作者信息
Deguchi Hiroshi, Navarro Silvia, Payne Amanda B, Elias Darlene J, Dowling Nicole F, Austin Harland D, España Francisco, Medina Pilar, Hooper W Craig, Griffin John H
机构信息
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, La Fe Medical Research Institute, Valencia, Spain.
出版信息
Res Pract Thromb Haemost. 2017 Jul;1(1):33-40. doi: 10.1002/rth2.12018. Epub 2017 Jun 23.
BACKGROUND
One previous pilot study suggested the association of low plasma glucosylceramide (GlcCer) levels with venous thrombosis (VTE) risk.
OBJECTIVE
We aimed to confirm and evaluate the association of low plasma GlcCer levels with VTE and myocardial infarction (MI) occurrence, respectively.
PATIENTS AND METHODS
We evaluated the association of GlcCer in two independent case-control studies of Caucasian VTE populations (N = 210 and 636) and one case-control study of Caucasian MI patients (N = 345).
RESULT
Plasma GlcCer levels in VTE patients were lower compared to controls in two independent VTE populations (5.0 vs 5.8 μg/mL, p = 0.003 for the Scripps registry, and 5.6 vs 6.0 μg/mL, p = 0.001 for the Valencia registry, respectively). A low plasma GlcCer level (below 10th percentile of controls) was associated with increased VTE occurrence [odds ratio (OR) = 3.7 (95%CI, 1.8-7.9) for Scripps registry and OR = 2.1 (95%CI, 1.3-3.3) for Valencia registry, respectively). For the MI study, the median GlcCer plasma level was lower in MI patients than in controls (4.3 vs 5.6 μg/mL, p<0.001), and a low level of GlcCer (below 10th percentile of control) was associated with higher MI occurrence [OR = 7.7, (95%CI, 4.3-13.8)].
CONCLUSION
Lower concentration of GlcCer was associated with VTE occurrence in two independent studies and also with MI occurrence in one study.
背景
一项先前的试点研究表明，血浆葡萄糖神经酰胺（GlcCer）水平低与静脉血栓形成（VTE）风险相关。
目的
我们旨在分别确认和评估血浆GlcCer水平低与VTE及心肌梗死（MI）发生之间的关联。
患者与方法
我们在两项白种人VTE人群的独立病例对照研究（N = 210和636）以及一项白种人MI患者的病例对照研究（N = 345）中评估了GlcCer的关联。
结果
在两项独立的VTE人群中，VTE患者的血浆GlcCer水平低于对照组（斯克里普斯登记处分别为5.0 vs 5.8 μg/mL，p = 0.003；巴伦西亚登记处分别为5.6 vs 6.0 μg/mL，p = 0.001）。血浆GlcCer水平低（低于对照组第10百分位数）与VTE发生增加相关[斯克里普斯登记处的比值比（OR）= 3.7（95%CI，1.8 - 7.9），巴伦西亚登记处的OR = 2.1（95%CI，1.3 - 3.3）]。对于MI研究，MI患者的血浆GlcCer中位数水平低于对照组（4.3 vs 5.6 μg/mL，p<0.001），且GlcCer水平低（低于对照组第10百分位数）与MI发生增加相关[OR = 7.7，（95%CI，4.3 - 13.8）]。
结论
在两项独立研究中，较低浓度的GlcCer与VTE发生相关，在一项研究中也与MI发生相关。
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