Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia.
Institute of Health and Biomedical Innovation (IHBI) and School of Psychological and Counselling, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia.
Psychiatry Res. 2018 Feb;260:193-198. doi: 10.1016/j.psychres.2017.11.069. Epub 2017 Nov 28.
Posttraumatic Stress Disorder (PTSD) is a debilitating psychiatric disorder with decreased general health prognosis and increased mortality. Inflammation has been hypothesised to be a link between PTSD and the most common co-morbid medical disorders. However, the relationship between inflammation and PTSD is not clear. Individual inflammatory markers have shown variable associations with PTSD. This study investigates the correlations between serum cytokines, PTSD and resilience in a cohort of Caucasian Vietnam combat veterans (n = 299). After correction for multiple testing, PTSD severity was correlated with small but significant decreases in interleukin 6 and interferon γ (p = 0.004, p = 0.013, respectively) whereas resilience was correlated with increased levels of interleukin 6 and interferon γ (p = 0.023; p = 0.007, respectively). Analyses of sub-symptoms of PTSD revealed that mood and arousal symptoms showed the most significant effect on interleukin 6 and interferon γ. More research is needed to further elucidate the mechanisms underlying the relationship between cytokine levels, PTSD sub-symptoms and trauma outcomes to improve the knowledge base of differences in trauma response and the biological system.
创伤后应激障碍（PTSD）是一种使人虚弱的精神疾病，其总体健康预后下降，死亡率增加。炎症被假设为 PTSD 与最常见的合并医学疾病之间的联系。然而，炎症与 PTSD 之间的关系尚不清楚。个别炎症标志物与 PTSD 表现出不同的相关性。本研究在一组白人越南参战老兵队列中（n = 299），调查了血清细胞因子、PTSD 和适应力之间的相关性。在进行多次检验校正后，PTSD 严重程度与白细胞介素 6 和干扰素 γ 显著降低相关（p = 0.004，p = 0.013），而适应力与白细胞介素 6 和干扰素 γ 水平升高相关（p = 0.023；p = 0.007）。对 PTSD 亚症状的分析表明，情绪和觉醒症状对白细胞介素 6 和干扰素 γ 的影响最大。需要进一步研究以阐明细胞因子水平、PTSD 亚症状和创伤结局之间关系的机制，以提高对创伤反应和生物学系统差异的认识。
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