Jafari Elham, Jarah-Najafabadi Najmeh Taghi, Jahanian-Najafabadi Ali, Poorirani Safoora, Hassanzadeh Farshid, Sadeghian-Rizi Sedighe
Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Res Pharm Sci. 2017 Dec;12(6):526-534. doi: 10.4103/1735-5362.217433.
Cyclic imides are a group of compounds which have valuable biological properties including cytotoxic, anti-inflammatory, antibacterial and antifungal activities. In this study, succinic and phthalic anhydrides were treated with glycinamide in pyridine to yield the corresponding amic acids. These amic acids underwent ring closure with acetic anhydride and anhydrous sodium acetate to form cyclic imides. In another procedure, succinic and phthalic anhydrides upon reaction with 2-amino-benzylamine in pyridine gave the corresponding cyclic imides. The imides were screened for their antimicrobial activities against three types of bacteria and one type of fungi. Phthalimide derived from benzylamine exhibited remarkable antimicrobial activity against .
环状酰亚胺是一类具有重要生物学特性的化合物，包括细胞毒性、抗炎、抗菌和抗真菌活性。在本研究中，琥珀酸酐和邻苯二甲酸酐在吡啶中与甘氨酰胺反应生成相应的酰胺酸。这些酰胺酸与乙酸酐和无水乙酸钠发生闭环反应形成环状酰亚胺。在另一个步骤中，琥珀酸酐和邻苯二甲酸酐在吡啶中与2-氨基苄胺反应得到相应的环状酰亚胺。对这些酰亚胺针对三种细菌和一种真菌的抗菌活性进行了筛选。源自苄胺的邻苯二甲酰亚胺对……表现出显著的抗菌活性。
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