Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
Eur J Med Chem. 2010 Apr;45(4):1552-9. doi: 10.1016/j.ejmech.2009.12.064. Epub 2010 Jan 13.
In an effort to establish new candidates with improved antibacterial activities, we reported here the synthesis and in vitro antibacterial evaluation of various series of 2-substituted-3a,4,9,9a-tetrahydro-4,9-benzeno-benz[f]isoindole-1,3-diones: 4-acetyl-phenyl 2, 2,2-dibromoacetylphenyl 3, benzimidazole 4, acetylbenzimidazole 5, aminophenyl 6, acetamide 7, naphthalene 8, disulfide 9, mercaptophenyl 10, hydroxyphenyl 11, phenyl ester 12, triazole 13, benzothiophene 14, benzothiazole 15 phenylazo 16a, b and aminomethane 17 derivatives. The newly synthesized compounds were characterized by (IR, (1)H NMR, (13)C NMR and mass spectrum studies). Representative compounds of the synthesized products were established and evaluated as antibacterial agents.
为了寻找具有更好抗菌活性的新候选药物，我们在这里报道了一系列 2-取代-3a,4,9,9a-四氢-4,9-苯并苯[f]异吲哚-1,3-二酮的合成和体外抗菌评价：4-乙酰基苯基 2, 2,2-二溴乙酰基苯基 3, 苯并咪唑 4, 乙酰苯并咪唑 5, 氨基苯基 6, 乙酰胺 7, 萘 8, 二硫醚 9, 巯基苯基 10, 羟基苯基 11, 苯基酯 12, 三唑 13, 苯并噻吩 14, 苯并噻唑 15 偶氮苯 16a,b 和甲胺 17 衍生物。新合成的化合物通过（IR、（1）H NMR、（13）C NMR 和质谱研究进行了表征。对合成产物的代表性化合物进行了鉴定，并将其评估为抗菌剂。
