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在药用水蛭疗法期间选择多重耐药菌。

selection of a multidrug-resistant during medicinal leech therapy.

作者信息

Ruppé E, Cherkaoui A, Wagner N, La Scala G C, Beaulieu J-Y, Girard M, Frey J, Lazarevic V, Schrenzel J

机构信息

Genomic Research Laboratory, Division of Infectious Diseases, Switzerland.

Bacteriology Laboratory, Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Switzerland.

出版信息

New Microbes New Infect. 2017 Oct 10;21:23-27. doi: 10.1016/j.nmni.2017.10.005. eCollection 2018 Jan.

DOI:10.1016/j.nmni.2017.10.005
PMID:29204282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5709350/
Abstract

We report the selection in a 15-year-old boy of a multidrug-resistant, extended-spectrum β-lactamase (ESBL)-producing after medicinal leech therapy that required an antibiotic prophylaxis based on piperacillin/tazobactam and cotrimoxazole. Whole genome sequencing of the strain indeed revealed 13 antibiotic resistance genes, including the ESBL CTX-M-3 and the unusual β-lactamase SCO-1.

摘要

我们报告了一名15岁男孩在接受药用水蛭疗法后，感染了一株产超广谱β-内酰胺酶（ESBL）的多重耐药菌，需要基于哌拉西林/他唑巴坦和复方新诺明进行抗生素预防。对该菌株进行全基因组测序确实发现了13个抗生素耐药基因，包括ESBL CTX-M-3和不常见的β-内酰胺酶SCO-1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/9a1f8d7b9ba8/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/97fab665870a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/2674e2171033/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/9a1f8d7b9ba8/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/97fab665870a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/2674e2171033/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f5b/5709350/9a1f8d7b9ba8/figs1.jpg

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