Knauert Melissa, Naik Sreelatha, Gillespie M Boyd, Kryger Meir
Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
Otolaryngology - Head & Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
World J Otorhinolaryngol Head Neck Surg. 2015 Sep 8;1(1):17-27. doi: 10.1016/j.wjorl.2015.08.001. eCollection 2015 Sep.
To provide an overview of the healthcare and societal consequences and costs of untreated obstructive sleep apnea syndrome.
PubMed database for English-language studies with no start date restrictions and with an end date of September 2014.
A comprehensive literature review was performed to identify all studies that discussed the physiologic, clinical and societal consequences of obstructive sleep apnea syndrome as well as the costs associated with these consequences. There were 106 studies that formed the basis of this analysis.
Undiagnosed and untreated obstructive sleep apnea syndrome can lead to abnormal physiology that can have serious implications including increased cardiovascular disease, stroke, metabolic disease, excessive daytime sleepiness, work-place errors, traffic accidents and death. These consequences result in significant economic burden. Both, the health and societal consequences and their costs can be decreased with identification and treatment of sleep apnea.
Treatment of obstructive sleep apnea syndrome, despite its consequences, is limited by lack of diagnosis, poor patient acceptance, lack of access to effective therapies, and lack of a variety of effective therapies. Newer modes of therapy that are effective, cost efficient and more accepted by patients need to be developed.
概述未经治疗的阻塞性睡眠呼吸暂停综合征对医疗保健及社会造成的后果和成本。
PubMed数据库，用于检索无起始日期限制且截至2014年9月的英文研究。
进行全面的文献综述，以识别所有讨论阻塞性睡眠呼吸暂停综合征的生理、临床和社会后果以及与这些后果相关成本的研究。共有106项研究构成了本分析的基础。
未诊断和未治疗的阻塞性睡眠呼吸暂停综合征可导致生理异常，进而产生严重影响，包括心血管疾病、中风、代谢疾病、日间过度嗜睡、工作场所失误、交通事故及死亡风险增加。这些后果会带来巨大的经济负担。通过识别和治疗睡眠呼吸暂停，可降低健康和社会后果及其成本。
尽管阻塞性睡眠呼吸暂停综合征会产生诸多后果，但其治疗仍受到诊断不足、患者接受度低、缺乏有效治疗途径以及有效治疗方法种类有限等因素的限制。需要开发出有效、成本效益高且更易被患者接受的新型治疗模式。
