Winokur G, Kadrmas A
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Compr Psychiatry. 1989 Mar-Apr;30(2):121-7. doi: 10.1016/0010-440x(89)90063-1.
Using archival data, we conducted a systematic study of consecutive admissions of bipolar patients and found that an early age of onset, a subacute onset, a family history of bipolarity, and the administration of electroconvulsive therapy (ECT) during an index episode were individually associated with a polyepisodic course of illness (three to nine or more episodes) during a period of observation which included onset of illness, index admission, and a period of follow-up. The family history of biopolarity which seems to predispose to multiple episodes suggests that what may be transmitted may not necessarily be a bipolar illness but possibly an illness with many episodes, thus increasing the likelihood of occurrence of a manic episode.
利用档案数据，我们对双相情感障碍患者的连续入院情况进行了一项系统性研究，发现发病年龄早、亚急性起病、双相情感障碍家族史以及在首次发作期间接受电休克治疗（ECT），分别与观察期（包括疾病发作、首次入院和随访期）内的多发作病程（三至九次或更多次发作）相关。似乎易导致多次发作的双相情感障碍家族史表明，可能遗传的不一定是双相情感障碍，而可能是一种发作多次的疾病，从而增加了躁狂发作的发生可能性。
