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现代血管腔内主动脉修复术的疗效

Outcomes of endovascular aortic repair in the modern era.

作者信息

Budtz-Lilly Jacob, Wanhainen Anders, Mani Kevin

机构信息

Department of Cardio-Thoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark -

Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden -

出版信息

J Cardiovasc Surg (Torino). 2018 Apr;59(2):180-189. doi: 10.23736/S0021-9509.17.10332-0. Epub 2017 Dec 4.

Abstract

Monitoring outcomes following endovascular aortic repair (EVAR) is critical. Although evidence from randomized controlled trials has solidified the role of EVAR, the analysis of outcomes and "real-world" data has uncovered limitations, improved the selection of appropriate patients, and underscored the importance of instructions for use. Subsequent studies demonstrated the learning curve of EVAR and gradual improvement of outcomes over time. Outcomes analyses will continue to play an important role, particularly as technological growth of endovascular therapy has enabled treatment of more complex aneurysm pathologies and patients. The important analyses are herein reviewed, following the development of EVAR in the treatment of intact abdominal aortic aneurysms (AAA) to ruptured AAAs, and finally to complex aneurysms, including thoracoabdominal aortic aneurysms and mycotic aneurysms. This includes an overview of the more recent results from analyses of branched and fenestrated EVAR, as well as the use of chimney grafts. It is emphasized that the success of endovascular repair has paradoxically been hampered by its rapid growth and early achievements. Even the most advanced engineering developments cannot overcome the long-term effects of the progression of aortic disease. The long-term benefits thus require careful planning and considerations of the natural history of aneurysms and the life expectancy of the patient. Large and international data registry collaborations should continue to play a role in providing outcomes analyses to guide future improvements.

摘要

监测血管内主动脉修复术(EVAR)后的结果至关重要。尽管随机对照试验的证据巩固了EVAR的作用,但对结果和“真实世界”数据的分析揭示了局限性,改进了合适患者的选择,并强调了使用说明的重要性。随后的研究证明了EVAR的学习曲线以及随着时间推移结果的逐渐改善。结果分析将继续发挥重要作用,特别是随着血管内治疗技术的发展能够治疗更复杂的动脉瘤病变和患者。本文回顾了重要的分析,从EVAR在治疗完整腹主动脉瘤(AAA)到破裂AAA,最后到复杂动脉瘤,包括胸腹主动脉瘤和感染性动脉瘤的发展历程。这包括对分支和开窗EVAR分析以及烟囱式移植物使用的最新结果的概述。需要强调的是,血管内修复术的成功反而因其快速发展和早期成果而受到阻碍。即使是最先进的工程进展也无法克服主动脉疾病进展的长期影响。因此,长期益处需要对动脉瘤的自然病史和患者的预期寿命进行仔细规划和考虑。大型国际数据登记合作应继续在提供结果分析以指导未来改进方面发挥作用。

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