帕金森病中 tau 成像的新进展。

New advances in tau imaging in parkinsonism.

机构信息

a Research Imaging Centre , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto , Toronto , ON , Canada.

b Division of Brain, Imaging and Behaviour-Systems Neuroscience , Krembil Research Institute, UHN, University of Toronto , Toronto , ON , Canada.

出版信息

Int Rev Psychiatry. 2017 Dec;29(6):628-635. doi: 10.1080/09540261.2017.1396446. Epub 2017 Dec 5.

DOI:10.1080/09540261.2017.1396446

PMID:29206491

Abstract

Currently, the differential diagnosis between atypical parkinsonisms and classical idiopathic Parkinson's disease can be quite difficult because of the significant overlap of clinical presentation and symptoms. Neurodegenerative conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal dementia (FTD), are primarily characterized by accumulation of tau protein in the brain. Recent imaging developments for tau pathology may provide a promising tool for the assessment of diagnosis, prognosis, and progression of these neurodegenerative disorders. This review will survey PET studies to describe the recent advances in the imaging of tau pathology in PSP, CBD, and FTD.

摘要

目前，由于临床症状和体征有很大的重叠，非典型帕金森病与经典特发性帕金森病的鉴别诊断可能相当困难。神经退行性疾病，包括进行性核上性麻痹（PSP）、皮质基底节变性（CBD）和额颞叶痴呆（FTD），主要表现为脑内 tau 蛋白的积累。tau 蛋白病理的最新成像进展可能为评估这些神经退行性疾病的诊断、预后和进展提供一种很有前途的工具。本综述将调查 PET 研究，以描述在 PSP、CBD 和 FTD 中 tau 病理成像的最新进展。