小儿患者心肌炎暴发报告：人疱疹病毒7型为病原体？
Report of a Myocarditis Outbreak among Pediatric Patients: Human Herpesvirus 7 as a Causative Agent?
作者信息
Ozdemir Rahmi, Kucuk Mehmet, Dibeklioglu Saime Ergen
机构信息
Department of Pediatric Cardiology, Dumlupinar University Kutahya Evliya Celebi Training and Research Hospital, Kutahya 43040, Turkey.
Department of Pediatric Cardiology, Samsun Maternal and Child Hospital, Samsun 55070, Turkey.
出版信息
J Trop Pediatr. 2018 Dec 1;64(6):468-471. doi: 10.1093/tropej/fmx093.
BACKGROUND
The etiology of myocarditis in children has not yet been completely elucidated.
OBJECTIVE
Medical records of eight pediatric patients diagnosed with acute myocarditis within a 41-day period in a small-town hospital were retrospectively analyzed.
METHODS
We examined antibody titers of adenovirus, Epstein-Barr virus, herpes simplex virus, respiratory syncytial virus, varicella-zoster virus and cytomegalovirus in peripheral blood. We used polymerase chain reaction (PCR) amplification to detect genetic sequences from Human herpesvirus (HHV) 7, HHV 6, enterovirus, measles or parvovirus in peripheral blood.
RESULTS
The causative agent was HHV 7 in four patients. HHV 7 sequences were detected through PCR in one patient with rapid deterioration. Of four patients with HHV 7, two presented with dilated cardiomyopathy.
CONCLUSION
To our knowledge, this is the first report to suggest HHV 7 as a causative agent for acute myocarditis. We believe HHV 7 should be considered as a possible etiologic pathogen for patients with suspected myocarditis.
背景
儿童心肌炎的病因尚未完全阐明。
目的
回顾性分析一家小镇医院在41天内诊断为急性心肌炎的8例儿科患者的病历。
方法
我们检测了外周血中腺病毒、EB病毒、单纯疱疹病毒、呼吸道合胞病毒、水痘-带状疱疹病毒和巨细胞病毒的抗体滴度。我们使用聚合酶链反应（PCR）扩增来检测外周血中人类疱疹病毒（HHV）7、HHV 6、肠道病毒、麻疹病毒或细小病毒的基因序列。
结果
4例患者的病原体为HHV 7。在1例病情迅速恶化的患者中通过PCR检测到HHV 7序列。在4例HHV 7患者中，2例出现扩张型心肌病。
结论
据我们所知，这是首次报道提示HHV 7为急性心肌炎的病原体。我们认为对于疑似心肌炎患者，应将HHV 7视为可能的病因病原体。
Zotero 插件